Ms. Melody Cai-Syaun Wu, Mr. Jack Hau-Ting Wei, Mr. Ricky Yu-Syun Fan, Ms. Eng Zhi Sim, Prof. Ken-Tye Yong, Prof. Tianxun Gong, Prof. Kien Voon Kong
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引用次数: 0
摘要
神经保护光疗的激动人心的突破！介绍Bpy-BODIPY@Au，一种尖端的纳米光敏剂，旨在加强神经退行性疾病的治疗。通过利用金纳米蛋白上BODIPY的j聚集，这种创新的结构促进了单线态氧的产生和光稳定性，有效地减少了tau蛋白的聚集——这是阿尔茨海默病的一个关键因素。这种有希望的治疗方法扩大了基于bodipy的纳米剂在治疗神经退行性疾病中的应用，展示了它们持久和靶向光疗的潜力。更多细节可以在第10.1002/ cic条中找到。202400562，作者：Yong kentye， Tianxun Gong， Kien Voon Kong及其同事。
Front Cover: Self-Assembled BODIPY@Au Core-Shell Structures for Durable Neuroprotective Phototherapy (ChemBioChem 3/2025)
Exciting breakthrough in neuroprotective phototherapy! Introducing Bpy-BODIPY@Au, a cutting-edge nanophotosensitizer designed to enhance treatment for neurodegenerative diseases. By using the J-aggregation of BODIPY on gold nanourchins, this innovative structure boosts singlet oxygen production and photostability, effectively reducing tau protein aggregation—a key factor in Alzheimer′s disease. This promising therapeutic approach expands the use of BODIPY-based nanoagents in treating neurodegenerative conditions, showcasing their potential for durable and targeted phototherapy. More details can be found in article 10.1002/cbic.202400562 by Ken-Tye Yong, Tianxun Gong, Kien Voon Kong, and co-workers.
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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