中国空肠弯曲杆菌的流行、抗生素耐药性、耐药性和毒力决定因素：系统综述和荟萃分析

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health Pub Date : 2025-02-10 DOI:10.1016/j.onehlt.2025.100990

Zhao Li , Hua Cai , Biyao Xu , Qingli Dong , Kai Jia , Zijie Lin , Xiang Wang , Yangtai Liu , Xiaojie Qin

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引用次数: 0

摘要

空肠弯曲杆菌（C. jejuni）被认为是一种严重的食品污染物，广泛导致食源性疾病。对空肠梭菌的流行和抗生素耐药性进行了大量研究，但缺乏对已发表数据的全面分析。本研究通过系统综述和荟萃分析，全面概述了中国空肠梭菌的流行病学、抗生素耐药性和毒力决定因素。空肠梭菌阳性率由低到高依次为人（5.2%,95% CI: 4.2 ~ 6.4%）、食物（12.5%,95% CI: 9.7 ~ 15.6%）、动物（15.4%,95% CI: 13.2 ~ 17.6%）和环境（17.8%,95% CI: 9.7 ~ 27.7%）。此外，空肠C.对头孢哌酮、萘啶酸、环丙沙星、头孢拉定和四环素等抗生素具有较高的耐药率。空肠梭菌总体耐多药率（MDR）为72.8% (95% CI: 62.4 ~ 82.2%)，耐多药问题严重。在过去的20年中，空肠梭菌对大多数抗生素的耐药性有所增加。在主要抗性决定因子中，gyrA_T86I和tet(O)的总阳性率较高，分别为94.8% （95% CI: 88.7 ~ 99.0%）和79.0% （95% CI: 66.9 ~ 89.2%）。此外，在空肠梭菌中，毒力相关基因如粘附基因（cadF、racR）、侵袭基因（ciaB、iamA、ceuE）和毒素基因（cdtB、cdtC）的发生率较高。综上所述，空肠梭菌具有较高的流行率和区域特征，在中国，该菌尤其是动物源的耐药问题仍然很严重。为保障食品安全和公众健康，迫切需要采取全面的监测和控制措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Prevalence, antibiotic resistance, resistance and virulence determinants of Campylobacter jejuni in China: A systematic review and meta-analysis

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Prevalence, antibiotic resistance, resistance and virulence determinants of Campylobacter jejuni in China: A systematic review and meta-analysis

Campylobacter jejuni (C. jejuni) is recognized as a serious food contaminant that extensively results in foodborne diseases. Numerous studies have been conducted on the prevalence and antibiotic resistance of C. jejuni, but there is a lack of comprehensive analysis of published data. This study provides a comprehensive overview of the epidemiology, antibiotic resistance, and virulence determinants of C. jejuni in China through a systematic review and meta-analysis. The prevalence levels of C. jejuni from low to high were the humans (5.2 %, 95 % CI: 4.2–6.4 %), foods (12.5 %, 95 % CI: 9.7–15.6 %), animals (15.4 %, 95 % CI: 13.2–17.6 %), and environment (17.8 %, 95 % CI: 9.7–27.7 %), respectively. Furthermore, C. jejuni exhibits high resistance rates to antibiotics such as cefoperazone, nalidixic acid, ciprofloxacin, cefradine, and tetracycline. The overall multi-drug resistance rate (MDR) of C. jejuni was 72.8 % (95 % CI: 62.4–82.2 %), indicating a serious problem with MDR. The resistance of C. jejuni to most antibiotics has increased in the last 20 years. Among the main resistance determinants of C. jejuni, gyrA_T86I and tet(O) had a higher pooled prevalence of 94.8 % (95 % CI: 88.7–99.0 %) and 79.0 % (95 % CI: 66.9–89.2 %), respectively. Furthermore, the high prevalence of virulence-related genes was shown in C. jejuni, such as adhesion (cadF, racR), invasion (ciaB, iamA, ceuE), and toxin (cdtB, cdtC). In summary, C. jejuni has a high prevalence with regional characteristics, and antibiotic resistance of this bacterium especially animal sources remains a serious problem in China. Comprehensive monitoring and control measures for this pathogen are urgently needed to ensure food safety and public health.

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来源期刊

One Health Medicine-Infectious Diseases

CiteScore

8.10

自引率

4.00%

发文量

审稿时长

18 weeks

期刊介绍： One Health - a Gold Open Access journal. The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information. Submissions to the following categories are welcome: Virology, Bacteriology, Parasitology, Mycology, Vectors and vector-borne diseases, Co-infections and co-morbidities, Disease spatial surveillance, Modelling, Tropical Health, Discovery, Ecosystem Health, Public Health.