作为仿生功能材料的红细胞衍生成分：基于结构和功能的匹配多用途递送策略

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-02-13 DOI:10.1016/j.bioactmat.2025.01.021

Hangbing Liu , Yi Li , Yuli Wang , Liying Zhang , Xiaoqing Liang , Chunsheng Gao , Yang Yang

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引用次数: 0

摘要

红细胞（rbc）通常被称为“智能递送系统”，由于其固有的优势和特性，可以作为生物或混合药物载体。这种创新的方法有可能提高生物相容性，药代动力学，并为药物提供靶向性。通过利用红细胞独特的结构和内容，可以精心设计药物装载途径以符合这些独特的特征。本文主要讨论了红细胞主要成分的结构和功能特性，包括活红细胞、膜、空心红细胞和血红蛋白的给药策略及其应用。综上所述，本文将有助于优化和合理利用基于红细胞衍生物的给药策略，为临床翻译的未来方向做出更好的决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Red blood cells-derived components as biomimetic functional materials: Matching versatile delivery strategies based on structure and function

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Red blood cells-derived components as biomimetic functional materials: Matching versatile delivery strategies based on structure and function

Red blood cells (RBCs), often referred to as "intelligent delivery systems", can serve as biological or hybrid drug carriers due to their inherent advantages and characteristics. This innovative approach has the potential to enhance biocompatibility, pharmacokinetics, and provide targeting properties for drugs. By leveraging the unique structure and contents of RBCs, drug-loading pathways can be meticulously designed to align with these distinctive features. This review article primarily discusses the drug delivery strategies and their applications that are informed by the structural and functional properties of the main components of RBCs, including living RBCs, membranes, hollow RBCs, and hemoglobin. Overall, this review article would assist efforts to make better decisions on optimization and rational utilization of RBCs derivatives-based drug delivery strategies for the future direction in clinical translation.

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.