基于多糖、蛋白质和DNA的刺激反应性水凝胶促进伤口愈合和修复：综述

IF 8.5 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-02-12 DOI:10.1016/j.ijbiomac.2025.140961

Yumo She , Peng Wu , Wenyu Wan , He Liu , Ruonan Liu , Tingting Wang , Mengyao Wang , Lufan Shen , Yuanyuan Yang , Xingyong Huang , Xiaoyue Zhang , Ye Tian , Kai Zhang

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引用次数: 0

摘要

各种伤口的愈合一直是医学领域面临的严峻挑战，水凝胶因其独特的网状结构而具有较高的亲水性和生物相容性，在伤口愈合领域显示出很强的优势。刺激反应性水凝胶尤其有效，可以根据外界刺激源控制材料性能，针对不同伤口提供更有针对性的治疗。本文综述了创伤愈合的生理机制、多糖、蛋白质和DNA刺激反应水凝胶与伤口愈合的关系、多糖、蛋白质和DNA刺激反应水凝胶的常用材料、刺激反应水凝胶的形成机制和网络结构类型、多糖的常见性质、基于蛋白质和DNA的刺激反应水凝胶促进伤口愈合，并讨论其在医学上的应用。最后，对多糖、蛋白质和DNA刺激反应水凝胶的局限性和应用前景进行了讨论和评价。本文综述了基于多糖、蛋白质和DNA的刺激反应水凝胶在伤口愈合和修复中的生物医学应用，并为临床相关材料的开发提供参考。

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Polysaccharides, proteins and DNA based stimulus responsive hydrogels promoting wound healing and repair: A review

The healing of various wounds remains a serious challenge in the medical field, hydrogel has high hydrophilicity and biocompatibility due to its unique network structure, which shows a strong advantage in the field of wound healing. Stimulus responsive hydrogels are particularly effective，which can control the material properties according to the external stimulus source, and provide more targeted treatment for different wounds. Here, we review physiological mechanisms of wound healing and the relationship between polysaccharides, proteins and DNA based stimulus responsive hydrogels and wound healing, materials commonly used of polysaccharides, proteins and DNA based stimulus responsive hydrogels, mechanisms of stimulus responsive hydrogels formation and network structure types, common properties of polysaccharides, proteins and DNA based stimulus responsive hydrogels for promoting wound healing and discuss their applications in medicine. Finally, the limitations and application prospects of polysaccharides, proteins and DNA based stimulus responsive hydrogels were discussed and evaluated. The review focuses on the biomedical use of polysaccharides, proteins and DNA based stimulus responsive hydrogels in wound healing and repair, and provides insights for the development of clinical related materials.

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.