富含蛋白质的口服营养补充剂对中老年妇女肌肉功能的影响：一项随机对照试验

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-02-13 DOI:10.1016/j.jnha.2025.100508

Minji Kang , Hyunkyung Rho , Minhui Kim , Miji Lee , Yunsook Lim , Jinmann Chon , Hyunjung Lim

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引用次数: 0

摘要

目的：本研究评估了连续12周服用富含蛋白质的口服营养补充剂（ONS）对中老年妇女肌肉质量、肌肉力量和功能的影响。设计一项单中心、双盲、随机对照试验研究对象为70名50-80岁的健康女性。干预和测量要求参与者每天使用两组测试ONS (Nucare Active, Daesang Wellife Corp.，首尔，大韩民国；200千卡/包，23克碳水化合物，6克脂肪，15克蛋白质，包括支链氨基酸或安慰剂ONS（200千卡/包，33克碳水化合物，8克脂肪，1克蛋白质），持续12周，同时保持正常的生活方式。主要终点是瘦体重（LBM），次要终点包括肌肉力量、体能、炎症标志物和体脂量（FM）。结果64例受试者(试验组33例，安慰剂组31例；平均±SD年龄，[试验组]63.06±5.51岁，[安慰剂组]63.29±3.28岁，p = 0.839)完成12周方案。试验组的LBM变化百分比高于安慰剂组(0.26% [95%CI: - 0.27, 0.78] vs. - 0.47% [95%CI: - 0.81, - 0.13]；P = 0.020)。安慰剂组FM显著增加(38.15% [95%CI: 36.62, 39.69]至38.67% [95%CI: 37.14, 40.21]；p & lt;0.01)。两组之间LBM/BMI和FM/BMI的变化也有明显的视觉差异。两组在肌肉力量、体能表现或炎症指标方面没有显著差异。结论富含蛋白质的ONS有助于维持中老年女性的LBM，防止FM增加。这表明它在预防与女性衰老相关的虚弱和肌肉骨骼疾病方面的潜在作用。

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Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial

Objectives

This study evaluated the effects of protein-enriched oral nutritional supplementation (ONS) consumption for 12 weeks on muscle mass, muscular strength, and function in middle-aged and elderly women.

Design

A single-center, double-blind, randomized controlled trial

Participants

This study was conducted with 70 healthy female participants aged 50–80.

Intervention and measurements

Participants were instructed to incorporate two daily packs of either the test ONS (Nucare Active, Daesang Wellife Corp., Seoul, Republic of Korea; 200 kcal/pack, 23 g carbohydrate, 6 g fat, and 15 g protein including branched chain amino acids or placebo ONS (200 kcal/pack, 33 g carbohydrate, 8 g fat, and 1 g protein) into their routine for 12 weeks while maintaining their regular lifestyle. The primary outcome was lean body mass (LBM), while secondary outcomes included muscular strength, physical performance ability, inflammatory markers, and body fat mass (FM).

Results

Sixty-four participants (33 in the test group, 31 in the placebo group; mean ± SD age, [test] 63.06 ± 5.51 years, [placebo] 63.29 ± 3.28 years, p = 0.839) completed the 12-week protocol. The test group exhibited a higher percentage change in LBM than the placebo group (0.26 % [95%CI: −0.27, 0.78] vs. −0.47 % [95%CI: −0.81, −0.13]; p = 0.020). The placebo group experienced a significant increase in FM (38.15 % [95%CI: 36.62, 39.69] to 38.67 % [95%CI: 37.14, 40.21]; p < 0.01). The difference in the changes in LBM/BMI and FM/BMI between the two groups was also visually distinct. There were no significant differences between the two groups in terms of muscular strength, physical performance ability, or inflammatory markers.

Conclusions

Protein-enriched ONS helped maintain LBM and prevent FM gain in middle-aged and elderly females. This suggests its potential role in preventing frailty and musculoskeletal disorders associated with female aging.

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.