木脂素对黑檀TNBC细胞的选择性抑制作用

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-13 DOI:10.1016/j.phytol.2025.02.002

Zhen Peng , Xin Han , Zhao Lu , Nan Fu , Rui Zhan

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引用次数: 0

摘要

为了寻找新的生物活性化合物，对细枝和叶片的石油醚提取物进行了研究。分离并鉴定了13个木脂素，其中4个为新化合物。它们的结构通过广泛的光谱分析和HRESIMS测定。对这些木脂素的抗增殖活性进行了测试。化合物3和4对三阴性乳腺癌细胞（MDA-MB-468）的抗增殖选择性优于her2阳性乳腺癌细胞（SKBr3和MCF-7）， SI值高达8。此外，3和4对正常乳腺细胞MCF-10A的毒性较小，代表了一类选择性抗增殖药物。

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Selective anti-proliferative lignans towards TNBC cells from Knema elegans (Myristicaceae)

Aiming to find new bioactive compounds from Knema elegans, the petroleum ether extract of the twigs and leaves were explored. As a result, thirteen lignans including four new ones were isolated and elucidated. Their structures were determined by extensive spectroscopic analysis and HRESIMS. These lignans were tested for their anti-proliferative activity. Compounds 3 and 4 showed anti-proliferative selectivity to triple negative breast cancer cells (MDA-MB-468) over HER2-positive breast cancer cells (SKBr3 and MCF-7) with SI values up to 8. Moreover, 3 and 4 exhibited less toxic on normal breast cells MCF-10A representing a class of selective anti-proliferative agents.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.