Min Ge, Wanbo Zhu, Jiawei Mei, Tingting Hu, Chuang Yang, Han Lin, Jianlin Shi
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Piezoelectric-Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis (Adv. Mater. 6/2025)
Biofilm Eradication
In article number 2409633, Min Ge, Chuang Yang, Han Lin, Jianlin Shi, and co-workers developed a physical and chemical barrier breakthrough strategy for biofilms via redox homeostasis manipulation. The nanosystem can enhance the attack of ROS via exogenous stimulation while providing interference with endogenous H2S synthase to reduce the resistance of reducing species, which together lead to severe structural damage in biofilms. In addition, oxidative stress mediates N1 polarization of neutrophils, leading to immunobactericidal effects.
期刊介绍:
Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.