[脑膜中动脉栓塞治疗慢性硬膜下血肿]。

Harefuah Pub Date : 2025-01-01
Dan Zharia Milikovsky, Oz Haim, Sharif Basal, Tali Jonas Kimchi, Udi Sadeh
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引用次数: 0

摘要

慢性硬膜下出血(CSDH)是神经外科干预的最常见原因之一。由于人口老龄化和抗凝和抗聚集处方药的增加,这种情况的发病率和患病率预计将增长。传统上,人们普遍认为出血是由脑脊液流向硬脑膜窦的桥静脉引起的。然而,最近的研究发现揭示了一个额外的潜在机制。创伤导致硬脑膜边界细胞层的分离,引起炎症过程,开始漏血管形成(血管增生)的正反馈,导致血液产物渗漏,进一步加剧炎症。多年来,对于有轻微临床和影像学特征的病例,该疾病一直采用保守治疗,或者在更严重的病例中采用手术清除血肿。文献显示,手术切除血液后的复发率一直很高,约为30%。新发现的机制激发了这种实体的一种新的治疗方法的发展。脑膜中动脉血管内栓塞术。该方法具有良好的疗效和安全性,可单独或联合手术抽吸。本文综述了CSDH的流行病学和机制,以及可能的治疗方法,并最终讨论了MMA栓塞术,以提高以色列医学界对这种新方法的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[EMBOLIZATION OF MIDDLE MENINGEAL ARTERY AS A TREATMENT FOR CHRONIC SUBDURAL HEMATOMA].

Introduction: Chronic subdural hemorrhage (CSDH) is one of the most common reasons for neurosurgical intervention. The incidence and prevalence of this condition is expected to grow due to aging of the population and the increase in anticoagulation and anti-aggregation prescription drugs. Traditionally, it was accepted that the bleeding originates from bridging veins that drain the brain towards the dural sinuses. However, recent findings exposed an additional underlying mechanism. Trauma leads to separation of the dural border cell layer which induces an inflammatory process that starts positive feedback of leaky blood vessels formation (angidysgensis), which causes blood product leakage that further increases the inflammation. For many years, the disease has been treated conservatively in cases of mild clinical and imaging features, or by surgical evacuation of the hematoma in more severe cases. The literature shows a consistent high recurrence rate of around 30% following a surgical removal of the blood. The newly discovered mechanism inspired the development of a novel treatment method for this entity. Endovascular embolization of the middle meningeal artery (MMA). This method has an excellent efficacy and safety profile, and it can be performed alone or in combination with surgical evacuation. This review presents the epidemiology and mechanisms underlying CSDH, in addition to possible treatment methods, and eventually discuss MMA embolization to increase the awareness of the medical community in Israel to this new approach.

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