产前睾酮暴露与7岁儿童身体组成的两性二态变化有关。

IF 5.1 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Camilla Viola Buskbjerg Palm, Anders Grøntved, Dorte Møller Jensen, Freja Pelck Hansen, Jan Stener Jørgensen, Henrik Thybo Christesen, Dorte Glintborg, Marianne Skovsager Andersen
{"title":"产前睾酮暴露与7岁儿童身体组成的两性二态变化有关。","authors":"Camilla Viola Buskbjerg Palm, Anders Grøntved, Dorte Møller Jensen, Freja Pelck Hansen, Jan Stener Jørgensen, Henrik Thybo Christesen, Dorte Glintborg, Marianne Skovsager Andersen","doi":"10.1210/clinem/dgaf085","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Maternal free testosterone (FT) increases during the third trimester and FT is higher in pregnant women with polycystic ovary syndrome (PCOS) compared to women without PCOS. Higher prenatal androgen exposure has previously been associated with increased catch-up growth in boys.</p><p><strong>Objective: </strong>This work aimed to examine associations between maternal third-trimester testosterone and body composition in boys and girls.</p><p><strong>Methods: </strong>This study comprised 1008 mother-child pairs (boys, n = 520) in the Odense Child Cohort (maternal PCOS, n = 101). Maternal FT was calculated from total testosterone (TT) analyzed by mass spectrometry at gestational week 28. Body composition assessments were performed in 7-year-old children by whole-body dual x-ray absorptiometry (DXA, n = 897) measuring body fat (fat mass index [FMI = fat mass(kg)/height(m)2]), percentages of total fat mass, gynoid, and android fat mass) and lean body mass, body weight, body mass index (BMI and BMI z scores), and abdominal circumference. The main outcome was body fat at age 7 years.</p><p><strong>Results: </strong>In boys, a doubling in FT was associated with a 4.2% increase in FMI (P = .04) and an increase in BMI and BMI z score of 0.2 and 0.1 (P = .05 and .04), respectively. In girls, no statistically significant association was observed between maternal FT and body composition.</p><p><strong>Conclusion: </strong>Boys exposed to higher prenatal levels of FT had higher fat mass, whereas no relation was seen in girls, suggesting a sex-specific susceptibility to prenatal testosterone exposure on child body composition.</p>","PeriodicalId":50238,"journal":{"name":"Journal of Clinical Endocrinology & Metabolism","volume":" ","pages":"e3225-e3234"},"PeriodicalIF":5.1000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prenatal Testosterone Exposure Is Linked to Sexually Dimorphic Changes in Body Composition in 7-Year-Old Children.\",\"authors\":\"Camilla Viola Buskbjerg Palm, Anders Grøntved, Dorte Møller Jensen, Freja Pelck Hansen, Jan Stener Jørgensen, Henrik Thybo Christesen, Dorte Glintborg, Marianne Skovsager Andersen\",\"doi\":\"10.1210/clinem/dgaf085\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Maternal free testosterone (FT) increases during the third trimester and FT is higher in pregnant women with polycystic ovary syndrome (PCOS) compared to women without PCOS. Higher prenatal androgen exposure has previously been associated with increased catch-up growth in boys.</p><p><strong>Objective: </strong>This work aimed to examine associations between maternal third-trimester testosterone and body composition in boys and girls.</p><p><strong>Methods: </strong>This study comprised 1008 mother-child pairs (boys, n = 520) in the Odense Child Cohort (maternal PCOS, n = 101). Maternal FT was calculated from total testosterone (TT) analyzed by mass spectrometry at gestational week 28. Body composition assessments were performed in 7-year-old children by whole-body dual x-ray absorptiometry (DXA, n = 897) measuring body fat (fat mass index [FMI = fat mass(kg)/height(m)2]), percentages of total fat mass, gynoid, and android fat mass) and lean body mass, body weight, body mass index (BMI and BMI z scores), and abdominal circumference. The main outcome was body fat at age 7 years.</p><p><strong>Results: </strong>In boys, a doubling in FT was associated with a 4.2% increase in FMI (P = .04) and an increase in BMI and BMI z score of 0.2 and 0.1 (P = .05 and .04), respectively. In girls, no statistically significant association was observed between maternal FT and body composition.</p><p><strong>Conclusion: </strong>Boys exposed to higher prenatal levels of FT had higher fat mass, whereas no relation was seen in girls, suggesting a sex-specific susceptibility to prenatal testosterone exposure on child body composition.</p>\",\"PeriodicalId\":50238,\"journal\":{\"name\":\"Journal of Clinical Endocrinology & Metabolism\",\"volume\":\" \",\"pages\":\"e3225-e3234\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Endocrinology & Metabolism\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1210/clinem/dgaf085\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Endocrinology & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1210/clinem/dgaf085","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

背景:母体游离睾酮(FT)在妊娠晚期增加,与未患多囊卵巢综合征(PCOS)的孕妇相比,患有多囊卵巢综合征(PCOS)的孕妇FT更高。以前,较高的产前雄激素暴露与男孩追赶性生长的增加有关。目的:探讨母亲孕晚期睾酮与男孩和女孩身体成分的关系。设计、环境和参与者:本研究包括欧登塞儿童队列(母体多囊卵巢综合征,n=101)的1008对母子(男孩,n=520)。从总睾酮(TT)中计算母体FT,并在妊娠28周通过质谱分析。采用全身双x线吸收仪(DXA, n=897)对7岁儿童进行体成分评估,测量体脂肪(脂肪质量指数(FMI =脂肪质量(kg)/身高(m)2)、总脂肪质量百分比、雌性和雄性脂肪质量)、瘦体重、体重、体重指数(BMI和BMI z分数)和腹围。主要结果:7岁时体脂。结果:在男孩中,FT加倍与FMI增加4.2%相关(p=0.04), BMI和BMI z-score分别增加0.2 kg/m2和0.1 (p=0.05和0.04)。在女孩中,没有观察到母体FT和身体成分之间的显著关联。结论:暴露于较高的产前FT水平的男孩有较高的脂肪量,而在女孩中没有发现相关;表明胎儿期睾酮暴露对儿童身体成分有性别特异性易感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prenatal Testosterone Exposure Is Linked to Sexually Dimorphic Changes in Body Composition in 7-Year-Old Children.

Context: Maternal free testosterone (FT) increases during the third trimester and FT is higher in pregnant women with polycystic ovary syndrome (PCOS) compared to women without PCOS. Higher prenatal androgen exposure has previously been associated with increased catch-up growth in boys.

Objective: This work aimed to examine associations between maternal third-trimester testosterone and body composition in boys and girls.

Methods: This study comprised 1008 mother-child pairs (boys, n = 520) in the Odense Child Cohort (maternal PCOS, n = 101). Maternal FT was calculated from total testosterone (TT) analyzed by mass spectrometry at gestational week 28. Body composition assessments were performed in 7-year-old children by whole-body dual x-ray absorptiometry (DXA, n = 897) measuring body fat (fat mass index [FMI = fat mass(kg)/height(m)2]), percentages of total fat mass, gynoid, and android fat mass) and lean body mass, body weight, body mass index (BMI and BMI z scores), and abdominal circumference. The main outcome was body fat at age 7 years.

Results: In boys, a doubling in FT was associated with a 4.2% increase in FMI (P = .04) and an increase in BMI and BMI z score of 0.2 and 0.1 (P = .05 and .04), respectively. In girls, no statistically significant association was observed between maternal FT and body composition.

Conclusion: Boys exposed to higher prenatal levels of FT had higher fat mass, whereas no relation was seen in girls, suggesting a sex-specific susceptibility to prenatal testosterone exposure on child body composition.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Clinical Endocrinology & Metabolism
Journal of Clinical Endocrinology & Metabolism 医学-内分泌学与代谢
CiteScore
11.40
自引率
5.20%
发文量
673
审稿时长
1 months
期刊介绍: The Journal of Clinical Endocrinology & Metabolism is the world"s leading peer-reviewed journal for endocrine clinical research and cutting edge clinical practice reviews. Each issue provides the latest in-depth coverage of new developments enhancing our understanding, diagnosis and treatment of endocrine and metabolic disorders. Regular features of special interest to endocrine consultants include clinical trials, clinical reviews, clinical practice guidelines, case seminars, and controversies in clinical endocrinology, as well as original reports of the most important advances in patient-oriented endocrine and metabolic research. According to the latest Thomson Reuters Journal Citation Report, JCE&M articles were cited 64,185 times in 2008.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信