{"title":"猫口腔鳞状细胞癌全舌下颌骨切除术20例疗效及手术并发症分析（2008-2022）","authors":"Taisuke Iwata, Masanao Ichimata, Atsushi Fujita, Yozo Shiraishi, Yumiko Kagawa, Atsushi Toshima, Tetsuya Kobayashi","doi":"10.1111/vco.13043","DOIUrl":null,"url":null,"abstract":"<p><p>Feline oral squamous cell carcinoma (FOSCC) is the most common oral malignancy in cats. In general, FOSCC develops rapidly and is highly locally invasive. The existing treatments for treating FOSCC are limited. The objective of this single-centre retrospective cohort study was to report the prognosis and surgical complications in cats that underwent total glosso-mandibulectomy (TGM) for feline oral squamous cell carcinoma (FOSCC). We investigated the medical records of 20 cats diagnosed with FOSCC by histopathologic examination and treated with TGM. The locations of FOSCC were in the mandible and tongue in 12 and 8 cats, respectively. All cats underwent percutaneous endoscopic gastrostomy. Postoperative complications of TGM were observed in 18 (90.0%) cats; incisional swelling was noted in 11 cats, including three cats with airway obstruction requiring management by tracheal intubation for several days. Postoperative anaemia was observed in 10 cats; two cats required blood transfusions. No cats died during the postoperative period. Progression-free interval (PFI) and overall survival time (OST) were 914 and 533 days, respectively. The 1- and 2-year survival rates were 50.2% and 37.8%, respectively. On univariate analysis, only histopathologic margin was associated with PFI and OST. TGM was successful in achieving long-term survival for FOSCC. Conversely, lifelong nutritional support via a gastrostomy tube and routine home care, including the removal of secretions from the palate and throat, was needed. There were no perioperative deaths, but serious complications occurred in some cats. The histopathologic margin was an important prognostic factor.</p>","PeriodicalId":23693,"journal":{"name":"Veterinary and comparative oncology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Outcomes and Surgical Complications of Cats With Oral Squamous Cell Carcinoma Treated With Total Glosso-Mandibulectomy: 20 Cases (2008-2022).\",\"authors\":\"Taisuke Iwata, Masanao Ichimata, Atsushi Fujita, Yozo Shiraishi, Yumiko Kagawa, Atsushi Toshima, Tetsuya Kobayashi\",\"doi\":\"10.1111/vco.13043\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Feline oral squamous cell carcinoma (FOSCC) is the most common oral malignancy in cats. In general, FOSCC develops rapidly and is highly locally invasive. The existing treatments for treating FOSCC are limited. The objective of this single-centre retrospective cohort study was to report the prognosis and surgical complications in cats that underwent total glosso-mandibulectomy (TGM) for feline oral squamous cell carcinoma (FOSCC). We investigated the medical records of 20 cats diagnosed with FOSCC by histopathologic examination and treated with TGM. The locations of FOSCC were in the mandible and tongue in 12 and 8 cats, respectively. All cats underwent percutaneous endoscopic gastrostomy. Postoperative complications of TGM were observed in 18 (90.0%) cats; incisional swelling was noted in 11 cats, including three cats with airway obstruction requiring management by tracheal intubation for several days. Postoperative anaemia was observed in 10 cats; two cats required blood transfusions. No cats died during the postoperative period. Progression-free interval (PFI) and overall survival time (OST) were 914 and 533 days, respectively. The 1- and 2-year survival rates were 50.2% and 37.8%, respectively. On univariate analysis, only histopathologic margin was associated with PFI and OST. TGM was successful in achieving long-term survival for FOSCC. Conversely, lifelong nutritional support via a gastrostomy tube and routine home care, including the removal of secretions from the palate and throat, was needed. There were no perioperative deaths, but serious complications occurred in some cats. The histopathologic margin was an important prognostic factor.</p>\",\"PeriodicalId\":23693,\"journal\":{\"name\":\"Veterinary and comparative oncology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-02-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary and comparative oncology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1111/vco.13043\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary and comparative oncology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/vco.13043","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
The Outcomes and Surgical Complications of Cats With Oral Squamous Cell Carcinoma Treated With Total Glosso-Mandibulectomy: 20 Cases (2008-2022).
Feline oral squamous cell carcinoma (FOSCC) is the most common oral malignancy in cats. In general, FOSCC develops rapidly and is highly locally invasive. The existing treatments for treating FOSCC are limited. The objective of this single-centre retrospective cohort study was to report the prognosis and surgical complications in cats that underwent total glosso-mandibulectomy (TGM) for feline oral squamous cell carcinoma (FOSCC). We investigated the medical records of 20 cats diagnosed with FOSCC by histopathologic examination and treated with TGM. The locations of FOSCC were in the mandible and tongue in 12 and 8 cats, respectively. All cats underwent percutaneous endoscopic gastrostomy. Postoperative complications of TGM were observed in 18 (90.0%) cats; incisional swelling was noted in 11 cats, including three cats with airway obstruction requiring management by tracheal intubation for several days. Postoperative anaemia was observed in 10 cats; two cats required blood transfusions. No cats died during the postoperative period. Progression-free interval (PFI) and overall survival time (OST) were 914 and 533 days, respectively. The 1- and 2-year survival rates were 50.2% and 37.8%, respectively. On univariate analysis, only histopathologic margin was associated with PFI and OST. TGM was successful in achieving long-term survival for FOSCC. Conversely, lifelong nutritional support via a gastrostomy tube and routine home care, including the removal of secretions from the palate and throat, was needed. There were no perioperative deaths, but serious complications occurred in some cats. The histopathologic margin was an important prognostic factor.
期刊介绍：
Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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