E G Kornetova, S A Galkin, I A Mednova, V V Tiguntsev, D Z Paderina, S A Ivanova
{"title":"[NOS1AP基因多态性与接受抗精神病药物治疗的精神分裂症患者QT间期持续时间的关系]。","authors":"E G Kornetova, S A Galkin, I A Mednova, V V Tiguntsev, D Z Paderina, S A Ivanova","doi":"10.17116/jnevro202512501198","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To study the associations of <i>NOS1AP</i> gene polymorphisms with the duration of the QT interval (QTc) in patients with schizophrenia receiving antipsychotics.</p><p><strong>Material and methods: </strong>One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three <i>NOS1AP</i> polymorphisms (rs12029454, rs10494366 and rs12143842) were selected for genotyping.</p><p><strong>Results: </strong>Spearman's correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (r<sub>s</sub>=0.262; <i>p=</i>0.021; <i>p</i><sub>Bonf</sub>=0.042). CPZeq was positively correlated with the duration of the QTc interval in men with <i>AA</i> and <i>AG</i> rs12029454 (r<sub>s</sub>=0.717; <i>p=</i>0.00025; <i>p</i><sub>bonf</sub>=0.0015), <i>GG</i> and <i>GT</i> rs10494366 (r<sub>s</sub>=0.381; <i>p=</i>0.008; <i>p</i><sub>bonf</sub>=0.048), <i>TT</i> and <i>CT</i> rs12143842 (r<sub>s</sub>=0.389; <i>p=</i>0.003; <i>p</i><sub>bonf</sub>=0.018) genotypes. We did not find any significant correlations in the group of women.</p><p><strong>Conclusion: </strong>Genetic variants rs12029454, rs10494366 and rs12143842 of the <i>NOS1AP</i> gene are associated with the duration of the QTc interval in men with schizophrenia in response to antipsychotics. The <i>AA</i>/<i>AG</i> rs12029454, <i>GG</i>/<i>GT</i> rs10494366 and <i>TT</i>/<i>CT</i> rs12143842 genotypes in men contribute to the prolongation of the QTc interval and the development of undesirable cardiovascular disorders against the background of antipsychotic therapy.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"98-104"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy].\",\"authors\":\"E G Kornetova, S A Galkin, I A Mednova, V V Tiguntsev, D Z Paderina, S A Ivanova\",\"doi\":\"10.17116/jnevro202512501198\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To study the associations of <i>NOS1AP</i> gene polymorphisms with the duration of the QT interval (QTc) in patients with schizophrenia receiving antipsychotics.</p><p><strong>Material and methods: </strong>One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three <i>NOS1AP</i> polymorphisms (rs12029454, rs10494366 and rs12143842) were selected for genotyping.</p><p><strong>Results: </strong>Spearman's correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (r<sub>s</sub>=0.262; <i>p=</i>0.021; <i>p</i><sub>Bonf</sub>=0.042). CPZeq was positively correlated with the duration of the QTc interval in men with <i>AA</i> and <i>AG</i> rs12029454 (r<sub>s</sub>=0.717; <i>p=</i>0.00025; <i>p</i><sub>bonf</sub>=0.0015), <i>GG</i> and <i>GT</i> rs10494366 (r<sub>s</sub>=0.381; <i>p=</i>0.008; <i>p</i><sub>bonf</sub>=0.048), <i>TT</i> and <i>CT</i> rs12143842 (r<sub>s</sub>=0.389; <i>p=</i>0.003; <i>p</i><sub>bonf</sub>=0.018) genotypes. We did not find any significant correlations in the group of women.</p><p><strong>Conclusion: </strong>Genetic variants rs12029454, rs10494366 and rs12143842 of the <i>NOS1AP</i> gene are associated with the duration of the QTc interval in men with schizophrenia in response to antipsychotics. The <i>AA</i>/<i>AG</i> rs12029454, <i>GG</i>/<i>GT</i> rs10494366 and <i>TT</i>/<i>CT</i> rs12143842 genotypes in men contribute to the prolongation of the QTc interval and the development of undesirable cardiovascular disorders against the background of antipsychotic therapy.</p>\",\"PeriodicalId\":56370,\"journal\":{\"name\":\"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova\",\"volume\":\"125 1\",\"pages\":\"98-104\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17116/jnevro202512501198\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/jnevro202512501198","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
[The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy].
Objective: To study the associations of NOS1AP gene polymorphisms with the duration of the QT interval (QTc) in patients with schizophrenia receiving antipsychotics.
Material and methods: One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three NOS1AP polymorphisms (rs12029454, rs10494366 and rs12143842) were selected for genotyping.
Results: Spearman's correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (rs=0.262; p=0.021; pBonf=0.042). CPZeq was positively correlated with the duration of the QTc interval in men with AA and AG rs12029454 (rs=0.717; p=0.00025; pbonf=0.0015), GG and GT rs10494366 (rs=0.381; p=0.008; pbonf=0.048), TT and CT rs12143842 (rs=0.389; p=0.003; pbonf=0.018) genotypes. We did not find any significant correlations in the group of women.
Conclusion: Genetic variants rs12029454, rs10494366 and rs12143842 of the NOS1AP gene are associated with the duration of the QTc interval in men with schizophrenia in response to antipsychotics. The AA/AG rs12029454, GG/GT rs10494366 and TT/CT rs12143842 genotypes in men contribute to the prolongation of the QTc interval and the development of undesirable cardiovascular disorders against the background of antipsychotic therapy.
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Одно из старейших медицинских изданий России, основанное в 1901 году. Создание журнала связано с именами выдающихся деятелей отечественной медицины, вошедших в историю мировой психиатрии и неврологии, – С.С. Корсакова и А.Я. Кожевникова.
Широкий диапазон предлагаемых журналом материалов и разнообразие форм их представления привлекают внимание научных работников и врачей, опытных и начинающих медиков, причем не только неврологов и психиатров, но и специалистов смежных областей медицины.
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