因果生存嵌入:右审查下的非参数反事实推理。

IF 1.6 3区 医学 Q3 HEALTH CARE SCIENCES & SERVICES
Statistical Methods in Medical Research Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI:10.1177/09622802241311455
Carlos García Meixide, Marcos Matabuena
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引用次数: 0

摘要

分布层面的反事实推理对审查目标提出了新的挑战,特别是在现代医疗保健问题中。为了减轻这种情况下的选择偏差,我们利用核均值嵌入的概念,利用核希尔伯特空间(RKHS)的内在结构来再现核希尔伯特空间。这使得反事实生存函数的非参数估计量得以发展。在与RKHS平滑相关的一般假设下,我们对新估计的一致性和收敛率提供了严格的理论保证。我们通过广泛的模拟和相关的案例研究来说明我们方法的实际可行性:SPRINT试验。与文献中的现有方法相比,我们的估计呈现出独特的视角,这些方法通常依赖于半参数方法,并且在模型参数的因果解释中面临局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Causal survival embeddings: Non-parametric counterfactual inference under right-censoring.

Counterfactual inference at the distributional level presents new challenges with censored targets, especially in modern healthcare problems. To mitigate selection bias in this context, we exploit the intrinsic structure of reproducing kernel Hilbert spaces (RKHS) harnessing the notion of kernel mean embedding. This enables the development of a non-parametric estimator of counterfactual survival functions. We provide rigorous theoretical guarantees regarding consistency and convergence rates of our new estimator under general hypotheses related to smoothness of the underlying RKHS. We illustrate the practical viability of our methodology through extensive simulations and a relevant case study: The SPRINT trial. Our estimatort presents a distinct perspective compared to existing methods within the literature, which often rely on semi-parametric approaches and confront limitations in causal interpretations of model parameters.

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来源期刊
Statistical Methods in Medical Research
Statistical Methods in Medical Research 医学-数学与计算生物学
CiteScore
4.10
自引率
4.30%
发文量
127
审稿时长
>12 weeks
期刊介绍: Statistical Methods in Medical Research is a peer reviewed scholarly journal and is the leading vehicle for articles in all the main areas of medical statistics and an essential reference for all medical statisticians. This unique journal is devoted solely to statistics and medicine and aims to keep professionals abreast of the many powerful statistical techniques now available to the medical profession. This journal is a member of the Committee on Publication Ethics (COPE)
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