烟酰胺及其对角质层水化和结构的影响。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Thomas Sjöberg, Andebrhan Fsahaye, Emelie J Nilsson, Silvia Letasiova, Itedale Namro, Lene Visdal-Johnsen, Nina Hrapovic, Sandra Smiljanic, Christina Österlund, Johan Engblom, Sebastian Björklund
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引用次数: 0

摘要

烟酰胺(NIA)因其良好的安全性、抗衰老效果和治疗各种皮肤病的临床疗效而被广泛用于护肤品中。然而,它对皮肤的主要屏障--角质层(SC)的水合作用和分子结构的直接影响仍不清楚。本研究探讨了 NIA 如何在不同的相对湿度(RH)水平下影响 SC 的脂质基质组织、软角蛋白结构和吸水行为。通过小角度和广角 X 射线衍射以及动态水汽吸附测量,我们比较了不同相对湿度下经过 NIA 处理的 SC 样品和未经处理的对照组。主要研究结果表明,虽然 NIA 不吸湿,但在高湿度(95% 相对湿度)条件下,它能增强 SC 的吸水性。在低湿度(60% 相对湿度)条件下,NIA 会膨胀角蛋白单体间距,尽管 SC 的含水量仍然很低,这表明它具有增塑作用,可以增加 SC 在干燥条件下的柔韧性。在 60% 和 95% 相对湿度条件下,NIA 还能改变脂质基质的衍射强度,这意味着它能与 SC 脂质基质相互作用,并影响 SC 脂质和蛋白质结构域内的水分分布。这些影响似乎与所研究的剂量制度无关,表明存在特定的浓度阈值。总之,NIA 与角蛋白有明显的相互作用,在干燥条件下会膨胀角蛋白单体之间的间距,但不会起到传统角质溶解剂的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Niacinamide and its impact on stratum corneum hydration and structure.

Niacinamide and its impact on stratum corneum hydration and structure.

Niacinamide and its impact on stratum corneum hydration and structure.

Niacinamide and its impact on stratum corneum hydration and structure.

Niacinamide (NIA) is widely used in skincare for its favorable safety profile, anti-aging effects, and proven clinical efficacy in treating various skin conditions. However, its direct impact on the hydration and molecular organization of the stratum corneum (SC), the primary skin barrier, remains unclear. This study examines how NIA influences the SC's lipid matrix organization, soft keratin structure, and water sorption behavior across varying relative humidity (RH) levels. Using small- and wide-angle X-ray diffraction and dynamic vapor sorption measurements, we compared NIA-treated SC samples to untreated controls under different RHs. The main findings show that while NIA is non-hygroscopic, it enhances water uptake of the SC at high humidity (95% RH). At low humidity (60% RH), NIA swells the keratin monomer spacing, although the SC water content remains low, suggesting a plasticizing effect that could increase SC flexibility in dry conditions. NIA also modifies the diffraction intensities from the lipid matrix differently at 60% and 95% RH, implying that it interacts with the SC lipid matrix and influences the water distribution within the SC lipid and protein domains. These effects appear independent of the investigated dose regime, indicating a specific concentration threshold. Overall, NIA shows distinct interaction with keratin, swelling the spacing between keratin monomers in dry conditions, without acting as a traditional keratolytic agent.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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