早中年体重指数轨迹与10年后阻塞性睡眠呼吸暂停风险

IF 6.6 2区 医学 Q1 RESPIRATORY SYSTEM
Respirology Pub Date : 2025-05-01 Epub Date: 2025-02-11 DOI:10.1111/resp.70002
Yaoyao Qian, Jennifer L Perret, Garun S Hamilton, Michael J Abramson, Caroline J Lodge, Dinh S Bui, Gulshan B Ali, Anurika P De Silva, Robert J Adams, Bruce R Thompson, Bircan Erbas, Eugene H Walters, Chamara V Senaratna, Shyamali C Dharmage
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引用次数: 0

摘要

背景和目的:虽然已知短期体重变化会影响阻塞性睡眠呼吸暂停(OSA),但在整个生命过程中,体重指数(BMI)变化的影响文献很少。我们研究了10年后从童年到中年的BMI轨迹与成年OSA之间的关系。方法:先前在以人群为基础的队列塔斯马尼亚纵向健康研究(TAHS)中确定了五个BMI轨迹,使用从5岁到43岁的八个时间点BMI。主要结局是53岁时可能的OSA,使用STOP-Bang问卷进行定义,使用Berlin和OSA-50问卷来确保结果的一致性。临床显著性诊断性OSA定义为自我报告的医学诊断或有症状的轻度OSA或中重度OSA,采用4型睡眠研究。使用多变量逻辑回归检验相关性。结果:与平均BMI轨迹相比,儿童BMI平均升高(aOR = 5.28, 95% CI 3.38-8.27)和持续高BMI轨迹(aOR = 3.73, 2.06-6.74)与可能的OSA风险增加相关。当使用具有临床意义的OSA诊断时,这些关联是一致的(儿童平均增加轨迹:aOR = 2.95, 1.30-6.72;高弹道:aOR = 2.23, 0.82-6.09)。处于低轨迹的个体比处于平均轨迹的个体患OSA的可能性要小。值得注意的是,儿童的高下降轨迹与OSA无关。结论:医生和公众应该意识到,从儿童期到45岁中期BMI较高或持续增加的中年人发生OSA的潜在风险。肥胖儿童减肥后中年时患阻塞性睡眠呼吸暂停的风险并不高——这是一个新颖而关键的发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early-to-Midlife Body Mass Index Trajectories and Obstructive Sleep Apnoea Risk 10 Years Later.

Background and objective: While short-term weight changes are known to influence obstructive sleep apnoea (OSA), the impact of body mass index (BMI) changes over the life course has been poorly documented. We examined the association between BMI trajectories from childhood to middle age and adult OSA, 10 years later.

Methods: Five BMI trajectories were previously identified in the population-based cohort Tasmanian Longitudinal Health Study (TAHS), using eight time-point BMI from age 5 to 43 years. The primary outcome was probable OSA at 53 years, defined using STOP-Bang questionnaire, with Berlin and OSA-50 questionnaires used to ensure consistency of findings. Clinically significant diagnosed OSA was defined as self-reported medical diagnosis or mild OSA with symptoms or moderate-to-severe OSA, using type-4 sleep studies. Associations were examined using multivariable logistic regression.

Results: Compared with the average BMI trajectory, the child average-increasing (aOR = 5.28, 95% CI 3.38-8.27) and persistently high trajectories (aOR = 3.73, 2.06-6.74) were associated with increased risk of probable OSA. These associations were consistent when using clinically significant diagnosed OSA (child average-increasing trajectory: aOR = 2.95, 1.30-6.72; high trajectory: aOR = 2.23, 0.82-6.09). Individuals belonging to the low trajectory were less likely than the average trajectory to have OSA. Notably, the child high-decreasing trajectory was not associated with OSA.

Conclusion: Physicians and the public should be aware of the potential risk of OSA in middle-aged adults when BMI is high or continuously increasing from childhood to mid-40s. Obese children who subsequently lose weight were not at higher risk of OSA in middle age-a novel and key finding.

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来源期刊
Respirology
Respirology 医学-呼吸系统
CiteScore
10.60
自引率
5.80%
发文量
225
审稿时长
1 months
期刊介绍: Respirology is a journal of international standing, publishing peer-reviewed articles of scientific excellence in clinical and clinically-relevant experimental respiratory biology and disease. Fields of research include immunology, intensive and critical care, epidemiology, cell and molecular biology, pathology, pharmacology, physiology, paediatric respiratory medicine, clinical trials, interventional pulmonology and thoracic surgery. The Journal aims to encourage the international exchange of results and publishes papers in the following categories: Original Articles, Editorials, Reviews, and Correspondences. Respirology is the preferred journal of the Thoracic Society of Australia and New Zealand, has been adopted as the preferred English journal of the Japanese Respiratory Society and the Taiwan Society of Pulmonary and Critical Care Medicine and is an official journal of the World Association for Bronchology and Interventional Pulmonology.
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