Darshan Shah, Rakesh Adelli, Alyson Chroust, Nicole Lewis, Martin Olsen
{"title":"门诊减少丁丙诺啡在阿片类药物使用障碍妊娠可能改善新生儿结局。","authors":"Darshan Shah, Rakesh Adelli, Alyson Chroust, Nicole Lewis, Martin Olsen","doi":"10.1038/s41372-025-02211-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The main objective of the study was to compare neonatal outcomes: the incidence of NOWS, length of hospital stay (LOS), admission to neonatal intensive care (NICU), birth weight, treatment with morphine, and head circumference between newborns of mothers who had tapering of buprenorphine (T group) during pregnancy to non-tapering of buprenorphine (NT group).</p><p><strong>Study design: </strong>It was a prospective, pilot, case-control trial of pregnant women done in North-East Tennessee in pregnancy with opioid use disorder (OUD) in the tapered (T) group as a part of clinical care while the NT group did not taper medication.</p><p><strong>Results: </strong>Significant differences were observed among neonatal outcomes; average birth weight and head circumference (p < 0.05) and admission to NICU (p < 0.05) between the two groups by t-test, and in maternal buprenorphine doses, 1.47 versus 7.6 (p < 0.0001).</p><p><strong>Conclusion: </strong>Comprehensive outpatient buprenorphine tapering can be done in OUD pregnancy with improved neonatal outcomes after careful discussion with providers of the risks and benefits.</p>","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":"480-486"},"PeriodicalIF":2.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069089/pdf/","citationCount":"0","resultStr":"{\"title\":\"Outpatient tapering of buprenorphine in opioid use disorder pregnancies may improve neonatal outcomes.\",\"authors\":\"Darshan Shah, Rakesh Adelli, Alyson Chroust, Nicole Lewis, Martin Olsen\",\"doi\":\"10.1038/s41372-025-02211-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The main objective of the study was to compare neonatal outcomes: the incidence of NOWS, length of hospital stay (LOS), admission to neonatal intensive care (NICU), birth weight, treatment with morphine, and head circumference between newborns of mothers who had tapering of buprenorphine (T group) during pregnancy to non-tapering of buprenorphine (NT group).</p><p><strong>Study design: </strong>It was a prospective, pilot, case-control trial of pregnant women done in North-East Tennessee in pregnancy with opioid use disorder (OUD) in the tapered (T) group as a part of clinical care while the NT group did not taper medication.</p><p><strong>Results: </strong>Significant differences were observed among neonatal outcomes; average birth weight and head circumference (p < 0.05) and admission to NICU (p < 0.05) between the two groups by t-test, and in maternal buprenorphine doses, 1.47 versus 7.6 (p < 0.0001).</p><p><strong>Conclusion: </strong>Comprehensive outpatient buprenorphine tapering can be done in OUD pregnancy with improved neonatal outcomes after careful discussion with providers of the risks and benefits.</p>\",\"PeriodicalId\":16690,\"journal\":{\"name\":\"Journal of Perinatology\",\"volume\":\" \",\"pages\":\"480-486\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069089/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Perinatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41372-025-02211-6\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41372-025-02211-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/10 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Outpatient tapering of buprenorphine in opioid use disorder pregnancies may improve neonatal outcomes.
Objective: The main objective of the study was to compare neonatal outcomes: the incidence of NOWS, length of hospital stay (LOS), admission to neonatal intensive care (NICU), birth weight, treatment with morphine, and head circumference between newborns of mothers who had tapering of buprenorphine (T group) during pregnancy to non-tapering of buprenorphine (NT group).
Study design: It was a prospective, pilot, case-control trial of pregnant women done in North-East Tennessee in pregnancy with opioid use disorder (OUD) in the tapered (T) group as a part of clinical care while the NT group did not taper medication.
Results: Significant differences were observed among neonatal outcomes; average birth weight and head circumference (p < 0.05) and admission to NICU (p < 0.05) between the two groups by t-test, and in maternal buprenorphine doses, 1.47 versus 7.6 (p < 0.0001).
Conclusion: Comprehensive outpatient buprenorphine tapering can be done in OUD pregnancy with improved neonatal outcomes after careful discussion with providers of the risks and benefits.
期刊介绍：
The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development.
The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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