不同穴居鱼种群血红蛋白升高通过不同血红蛋白基因表达模式进化。

IF 1.8 3区 生物学 Q3 DEVELOPMENTAL BIOLOGY
Tyler E. Boggs, Joshua B. Gross
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引用次数: 0

摘要

尽管有黑暗、饥饿和缺氧的压力,穴居动物在孤立的洞穴中茁壮成长。先前的研究表明,与生活在水面的鱼类相比,来自不同洞穴的Astyanax穴居鱼类表达的血红蛋白水平明显更高。有趣的是,尽管在正常氧气条件下圈养,但不同种群的洞穴鱼都保持着这种高度。我们利用圈养洞穴鱼血红蛋白升高的一致反应,这些鱼来自不同的地理区域,以确定这种升高是否由相同的Hb基因表达支撑。血红蛋白是由血红蛋白(Hb)基因家族成员组成的大家族编码的,它们表现出协调的表达模式,受到各种生物体(如生活史时期)和环境影响(如氧气供应)的影响。令人惊讶的是,我们发现地理上不同的人群表现出大多数不同的Hb基因表达模式。来自Pachón和Tinaja两个洞穴地区的洞穴鱼具有更近的共同起源,并且在成年时表现出更相似的Hb表达模式。然而,在胚胎期,Pachón和Tinaja在Hb家族成员的峰值表达时间上表现出显著的差异。总之,Hb基因表达的转录组学基础代表了三个圈养洞穴鱼种群共享和不同表达模式的复杂组合。我们得出结论,这些不同的模式可能受到生活史的影响,以及这些动物进化的独特洞穴条件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Elevated Blood Hemoglobin in Different Cavefish Populations Evolves Through Diverse Hemoglobin Gene Expression Patterns

Elevated Blood Hemoglobin in Different Cavefish Populations Evolves Through Diverse Hemoglobin Gene Expression Patterns

Cave-dwelling animals thrive in isolated caves despite the pressures of darkness, starvation, and reduced oxygen. Prior work revealed that Astyanax cave-dwelling morphs derived from different cave localities express significantly higher levels of blood hemoglobin compared to surface-dwelling fish. Interestingly, this elevation is maintained in different populations of cavefish, despite captive rearing in normal oxygen conditions. We capitalized on the consistent response of elevated hemoglobin in captive cavefish, which were derived from geographically distinct regions, to determine if this elevation is underpinned by expression of the same Hb genes. Blood hemoglobin proteins are encoded by a large family of hemoglobin (Hb) gene family members, which demonstrate coordinated expression patterns, subject to various organismal (e.g., period of life history) and environmental influences (e.g., oxygen availability). Surprisingly, we found that geographically distinct populations showed mostly divergent patterns of Hb gene expression. Cavefish from two cave localities, Pachón and Tinaja, have a more recent shared origin, and show more similar Hb expression patterns as adults. However, during embryonic phases, Pachón and Tinaja show significant variability in timing of peak expression of Hb family members. In sum, the transcriptomic underpinnings of Hb gene expression represents a complex composite of shared and divergent expression patterns across three captive cavefish populations. We conclude that these differential patterns are likely influenced by life history, and the unique cave conditions in which these animals evolved.

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来源期刊
CiteScore
4.80
自引率
9.10%
发文量
63
审稿时长
6-12 weeks
期刊介绍: Developmental Evolution is a branch of evolutionary biology that integrates evidence and concepts from developmental biology, phylogenetics, comparative morphology, evolutionary genetics and increasingly also genomics, systems biology as well as synthetic biology to gain an understanding of the structure and evolution of organisms. The Journal of Experimental Zoology -B: Molecular and Developmental Evolution provides a forum where these fields are invited to bring together their insights to further a synthetic understanding of evolution from the molecular through the organismic level. Contributions from all these branches of science are welcome to JEZB. We particularly encourage submissions that apply the tools of genomics, as well as systems and synthetic biology to developmental evolution. At this time the impact of these emerging fields on developmental evolution has not been explored to its fullest extent and for this reason we are eager to foster the relationship of systems and synthetic biology with devo evo.
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