表征正常范围内血尿素氮水平与美国成年人甲状腺功能之间的关系:NHANES 2007-2012研究结果

IF 1.8 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Hormone and Metabolic Research Pub Date : 2025-02-01 Epub Date: 2025-02-10 DOI:10.1055/a-2508-8034
Junru Liu, Xiaofeng Lu, Xiaotao Zhu, Jialu Song, Xiaogang Zheng, Chaoyang Xu, Huijing Tong, Mingzheng Wang
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引用次数: 0

摘要

血尿素氮(BUN)是评估患者肾功能的关键指标。慢性肾脏疾病患者也常表现为甲状腺功能异常。然而,BUN与甲状腺功能之间的具体联系尚不清楚。因此,本研究旨在探讨美国成年人正常范围内的BUN水平与甲状腺活动之间的关系。这些分析利用了国家健康和营养检查调查(NHANES)数据集。采用线性回归和平滑曲线拟合方法检验BUN水平与甲状腺功能测量之间的关系,并进行适当的加权和亚组分析。2007-2012年NHANEs循环纳入6231名符合条件的成人,BUN水平在2.5-8.0 mmol/l之间。在调整后的模型中,较高的BUN水平与FT3的减少相关(β=-0.01;p=0.047), TT3 (β=-1.08;p=0.003), TT4 (β=-0.10;p = 0.003)的水平。在亚组分析中,在不运动和运动的受试者中,BUN水平分别与FT3和TT4水平呈负相关。这些发现与美国成年人在正常范围内FT3、TT4和TT4水平降低与BUN水平升高相关是一致的。在不运动的受试者中,FT3水平与BUN水平升高的关系更为密切,而在运动的受试者中,TT4水平与BUN水平升高的关系更为密切。然而,进一步的研究对于阐明这些结果背后的机制至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterizing the Association Between Blood Urea Nitrogen Levels within the Normal Range and Thyroid Function Among US Adults: NHANES 2007-2012 Findings.

Blood urea nitrogen (BUN) is a key metric when evaluating the renal function of a given patient. Individuals with chronic kidney disease also often present with abnormal thyroid functionality. The specific association between BUN and thyroid function, however, is not well understood. This study was thus developed to explore how BUN levels within the normal range are related to thyroid activity among adults in the USA. The National Health and Nutrition Examination Survey (NHANES) dataset was leveraged for these analyses. Linear regression and smoothed curve fitting approaches were employed to examine the association between BUN levels and measures of thyroid function, with appropriate weighted and subgroup analyses. The 2007-2012 NHANEs cycles included 6231 eligible adults with BUN levels from 2.5-8.0 mmol/l. Under adjusted models, a higher BUN level was associated with reductions in FT3 (β=-0.01; p=0.047), TT3 (β=-1.08; p=0.003), and TT4 (β=-0.10; p=0.003) levels. In subgroup analyses, BUN levels were respectively found to be negatively correlated with FT3 and TT4 levels in subjects who were inactive and active. These findings are consistent with reduced FT3, TT4, and TT4 levels being correlated with higher BUN levels within the normal range among American adults. In non-physically active subjects, FT3 levels were more closely related to increasing BUN levels, whereas TT4 levels were more closely related to BUN levels among physically active subjects. However, additional research will be vital to clarify the mechanisms that underlie these results.

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来源期刊
Hormone and Metabolic Research
Hormone and Metabolic Research 医学-内分泌学与代谢
CiteScore
3.80
自引率
0.00%
发文量
125
审稿时长
3-8 weeks
期刊介绍: Covering the fields of endocrinology and metabolism from both, a clinical and basic science perspective, this well regarded journal publishes original articles, and short communications on cutting edge topics. Speedy publication time is given high priority, ensuring that endocrinologists worldwide get timely, fast-breaking information as it happens. Hormone and Metabolic Research presents reviews, original papers, and short communications, and includes a section on Innovative Methods. With a preference for experimental over observational studies, this journal disseminates new and reliable experimental data from across the field of endocrinology and metabolism to researchers, scientists and doctors world-wide.
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