补体因子H的眼部定位及其与眼部疾病的关系。

4区 医学 Q2 Biochemistry, Genetics and Molecular Biology
Rayne R Lim, Jennifer R Chao
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引用次数: 0

摘要

补体系统是免疫系统中一个有充分证据的组成部分,它保护身体免受外部病原体的侵害。虽然大多数补体成分是由肝脏产生并分泌到血液循环中,但眼组织也产生几种补体成分,从而促进眼睛特定区域的局部补体活性。补体级联激活的调节是防止意外细胞损伤的关键。在补体系统的替代途径中,补体因子H (CFH)在抑制调控中起着重要作用。某些导致CFH缺陷的基因多态性与罕见疾病有关,在这些疾病中,自我受到过度活跃的补体系统的攻击。本文将重点讨论CFH在人眼组织中的表达和定位,并强调其与眼球前房和后房几种疾病的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ocular Localization of Complement Factor H and Its Association with Diseases in the Eye.

The complement system is a well-documented element of the immune system that protects the body from external pathogens. Although the majority of complement components are produced by the liver and secreted into the circulation, ocular tissues also produce several complement components, thereby contributing to local complement activity in specific regions of the eye. Regulation of complement cascade activation is crucial for preventing unintended cellular damage. In the alternative pathway of the complement system, complement factor H (CFH) plays an important role in inhibitory regulation. Certain genetic polymorphisms that result in defective CFH are associated with rare diseases where the self is attacked by an overactive complement system. This review will focus on the expression and localization of CFH in human ocular tissues and highlight its association with several diseases in the anterior and posterior chambers of the eye.

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来源期刊
Advances in experimental medicine and biology
Advances in experimental medicine and biology 医学-医学:研究与实验
CiteScore
5.90
自引率
0.00%
发文量
465
审稿时长
2-4 weeks
期刊介绍: Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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