{"title":"与老年性黄斑变性相关的 RPE 基底薄层生物学和病理生理学。","authors":"Steffi Daniel, Antonio J Ortega, John D Hulleman","doi":"10.1007/978-3-031-76550-6_3","DOIUrl":null,"url":null,"abstract":"<p><p>Age-related macular degeneration (AMD) is a progressive eye disease that primarily affects the central part of the retina and is a leading cause of vision impairment worldwide (Wong WL, Su X, Li X, Lancet Glob Health 2:e106-116, 2014). Sub-retinal pigment epithelium (RPE) deposits represent a broadly defined term encompassing compositionally and anatomically distinct protein and lipid aggregates (i.e., drusen, basal linear deposits [BLinDs], and basal laminar deposits [BLamDs]). These deposits play a pivotal role in the pathogenesis of AMD and act as both key indicators and contributors to disease progression (van der Schaft TL, de Bruijn WC, Mooy CM, de Jong PT, Graefes Arch Clin Exp Ophthalmol 231:470-475, 1993; Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP, Br J Ophthalmol 83:358-368, 1999; Sura AA, Chen L, Messinger JD, Invest Ophthalmol Vis Sci 61:19, 2020). Thus, understanding factors that influence sub-RPE deposit formation is crucial, especially in the context of retinal health and disease (Loeffler KU, Lee WR, Br J Ophthalmol 82:1104-1105, 1998; Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP, Br J Ophthalmol 83:358-368, 1999). In this mini review, we have gathered and discussed valuable insights to provide a comprehensive overview focusing on BLamDs and their relevance to retinal disease.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":"1468 ","pages":"15-19"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"RPE Basal Lamina Biology and Pathophysiology Related to Age-Related Macular Degeneration.\",\"authors\":\"Steffi Daniel, Antonio J Ortega, John D Hulleman\",\"doi\":\"10.1007/978-3-031-76550-6_3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Age-related macular degeneration (AMD) is a progressive eye disease that primarily affects the central part of the retina and is a leading cause of vision impairment worldwide (Wong WL, Su X, Li X, Lancet Glob Health 2:e106-116, 2014). Sub-retinal pigment epithelium (RPE) deposits represent a broadly defined term encompassing compositionally and anatomically distinct protein and lipid aggregates (i.e., drusen, basal linear deposits [BLinDs], and basal laminar deposits [BLamDs]). These deposits play a pivotal role in the pathogenesis of AMD and act as both key indicators and contributors to disease progression (van der Schaft TL, de Bruijn WC, Mooy CM, de Jong PT, Graefes Arch Clin Exp Ophthalmol 231:470-475, 1993; Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP, Br J Ophthalmol 83:358-368, 1999; Sura AA, Chen L, Messinger JD, Invest Ophthalmol Vis Sci 61:19, 2020). Thus, understanding factors that influence sub-RPE deposit formation is crucial, especially in the context of retinal health and disease (Loeffler KU, Lee WR, Br J Ophthalmol 82:1104-1105, 1998; Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP, Br J Ophthalmol 83:358-368, 1999). In this mini review, we have gathered and discussed valuable insights to provide a comprehensive overview focusing on BLamDs and their relevance to retinal disease.</p>\",\"PeriodicalId\":7270,\"journal\":{\"name\":\"Advances in experimental medicine and biology\",\"volume\":\"1468 \",\"pages\":\"15-19\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in experimental medicine and biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/978-3-031-76550-6_3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in experimental medicine and biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/978-3-031-76550-6_3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
摘要
老年性黄斑变性（AMD）是一种进展性眼病，主要影响视网膜中央部分，是全球视力受损的主要原因之一（Wong WL, Su X, Li X, Lancet Glob Health 2:e106-116, 2014）。视网膜下色素上皮（RPE）沉积物是一个广义的术语，包括成分和解剖学上不同的蛋白质和脂质聚集体（即色素沉着、基底线性沉积物[BLinDs]和基底片状沉积物[BLamDs]）。这些沉积物在老年性视网膜病变的发病机制中起着关键作用，既是疾病进展的关键指标，也是疾病进展的促成因素（van der Schaft TL, de Bruijn WC, Mooy CM, de Jong PT, Graefes Arch Clin Exp Ophthalmol 231:470-475, 1993; Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP, Br J Ophthalmol 83:358-368, 1999; Sura AA, Chen L, Messinger JD, Invest Ophthalmol Vis Sci 61:19, 2020）。因此，了解影响 RPE 下沉积物形成的因素至关重要，尤其是在视网膜健康和疾病的背景下（Loeffler KU、Lee WR，Br J Ophthalmol 82：1104-1105，1998；Sarks SH、Arnold JJ、Killingsworth MC、Sarks JP，Br J Ophthalmol 83：358-368，1999）。在这篇小型综述中，我们收集并讨论了一些有价值的观点，以 BLamDs 及其与视网膜疾病的相关性为重点，提供了一份全面的综述。
RPE Basal Lamina Biology and Pathophysiology Related to Age-Related Macular Degeneration.
Age-related macular degeneration (AMD) is a progressive eye disease that primarily affects the central part of the retina and is a leading cause of vision impairment worldwide (Wong WL, Su X, Li X, Lancet Glob Health 2:e106-116, 2014). Sub-retinal pigment epithelium (RPE) deposits represent a broadly defined term encompassing compositionally and anatomically distinct protein and lipid aggregates (i.e., drusen, basal linear deposits [BLinDs], and basal laminar deposits [BLamDs]). These deposits play a pivotal role in the pathogenesis of AMD and act as both key indicators and contributors to disease progression (van der Schaft TL, de Bruijn WC, Mooy CM, de Jong PT, Graefes Arch Clin Exp Ophthalmol 231:470-475, 1993; Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP, Br J Ophthalmol 83:358-368, 1999; Sura AA, Chen L, Messinger JD, Invest Ophthalmol Vis Sci 61:19, 2020). Thus, understanding factors that influence sub-RPE deposit formation is crucial, especially in the context of retinal health and disease (Loeffler KU, Lee WR, Br J Ophthalmol 82:1104-1105, 1998; Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP, Br J Ophthalmol 83:358-368, 1999). In this mini review, we have gathered and discussed valuable insights to provide a comprehensive overview focusing on BLamDs and their relevance to retinal disease.
期刊介绍：
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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