血清肌酸水平作为烟雾病患者术后脑血管事件的预测因素

IF 2.7 3区 心理学 Q2 BEHAVIORAL SCIENCES
Siqi Mou, Zhikang Zhao, Chenglong Liu, Junsheng Li, Qiheng He, Wei Liu, Bojian Zhang, Zhiyao Zheng, Wei Sun, Xiangjun Shi, Qian Zhang, Rong Wang, Yan Zhang, Peicong Ge, Dong Zhang
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引用次数: 0

摘要

背景肌酸对于细胞内外的能量储存和转移至关重要。然而,其与脑血管疾病的关系尚未得到充分探讨。本研究探讨了烟雾病(MMD)患者血清肌酸水平与术后脑血管事件(包括短暂性脑缺血发作(TIA)、缺血性脑卒中和出血性脑卒中)之间的关系。方法采用液相色谱-串联质谱法测定352例烟雾病患者血清肌酸和磷酸肌酸二钠水平。Kaplan-Meier (KM)曲线用于分析血清肌酸水平对脑血管事件风险的影响,而单因素和多因素Cox回归分析用于确定术后结局的预测因素。我们开发了一种预测术后12个月、24个月和36个月无卒中生存的预后图。结果烟雾病患者血清肌酸与肌酐呈负相关(r = - 0.22;p & lt;0.001)和同型半胱氨酸(r = - 0.10;p & lt;0.05),但与磷酸肌酸二钠无关(r = - 0.08;p = 0.15)。根据血清肌酸中位数浓度将患者分为高、低两组,KM曲线分析显示,高浓度组患者发生脑血管事件的相对危险度低于低浓度组(风险比:0.55;95%置信区间为0.33-0.94;p = 0.026)。此外,当根据肌酸浓度将患者分为三个水平时,总体KM曲线分析显示差异有统计学意义(p = 0.038),即肌酸浓度最高组(第三个四分位数)与最低浓度组(第一个四分位数;p = 0.04)。结论较低的术前血清肌酸水平与烟雾病患者术后脑血管事件的高风险相关。因此,补充肌酸可能是预防烟雾病患者不良后果的有效手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Serum Creatine Levels as a Predictive Factor for Postoperative Cerebrovascular Events in Patients With Moyamoya Disease

Serum Creatine Levels as a Predictive Factor for Postoperative Cerebrovascular Events in Patients With Moyamoya Disease

Background

Creatine is essential for energy storage and transfer within and outside cells. However, its relationship with cerebrovascular disease has not been fully explored. This study examined the association between serum creatine levels and postoperative cerebrovascular events, including transient ischemic attack (TIA), ischemic stroke, and hemorrhagic stroke, in patients with moyamoya disease (MMD).

Methods

Serum creatine and disodium creatine phosphate levels were quantified in 352 patients with MMD using liquid chromatography–tandem mass spectrometry. Kaplan–Meier (KM) curves were used to analyze the impact of serum creatine levels on cerebrovascular event risk, whereas univariate and multivariate Cox regression analyses were used to identify predictors of postoperative outcomes. A prognostic nomogram was developed to predict stroke-free survival at 12, 24, and 36 months postoperatively.

Results

In patients with MMD, serum creatine showed a negative correlation with creatinine (r = −0.22; p < 0.001) and homocysteine (r = −0.10; p < 0.05) but not with disodium creatine phosphate (r = −0.08; p = 0.15). When patients were divided into high and low groups based on the median serum creatine concentration, KM curve analysis revealed that patients in the high concentration group had a lower relative risk of cerebrovascular events than those in the low concentration group (hazard ratio: 0.55; 95% confidence interval, 0.33–0.94; p = 0.026). Furthermore, when patients were categorized into three levels based on creatine concentration, the overall KM curve analysis showed a significant difference (p = 0.038), such that the highest creatine concentration group (third tertile) showed a significantly reduced risk compared with the lowest concentration group (first tertile; p = 0.04).

Conclusion

Lower preoperative serum creatine levels were associated with a higher risk of postoperative cerebrovascular events in patients with MMD. Therefore, creatine supplementation may be an effective means of preventing adverse outcomes in patients with MMD.

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来源期刊
Brain and Behavior
Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
5.30
自引率
0.00%
发文量
352
审稿时长
14 weeks
期刊介绍: Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)
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