伤脑筋的蠕虫

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-02-11 DOI:10.1016/j.immuni.2025.01.014

Yisi Lu, Ruaidhrí Jackson

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引用次数: 0

摘要

肠道神经系统是炎症的关键调节因子，与胃肠道粘膜表面的免疫系统直接交叉。在这一期的《免疫》杂志上，Wang和他的同事证明，在蠕虫感染期间，肠道内神经元（iENs）感知白细胞介素(IL)-13来抑制2组先天淋巴样细胞（ILC2）的活性，揭示了一种新的神经-免疫调节回路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nerve-racking worms

The enteric nervous system is a key regulator of inflammation, crosstalking directly with the immune system at the mucosal surfaces of the gastrointestinal tract. In this issue of Immunity, Wang and colleagues demonstrate that intrinsic enteric neurons (iENs) sense interleukin (IL)-13 to restrain group 2 innate lymphoid cell (ILC2) activity during helminth infection, uncovering a novel neuro-immune-regulatory circuit.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.