切中要害：修剪同种异体反应性T细胞

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-02-11 DOI:10.1016/j.immuni.2025.01.005

Anita S. Chong, Marlena Habal

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引用次数: 0

摘要

CD4+ T细胞对宿主MHC II类抗原呈递的供体肽的间接异体识别，部分通过引发供体特异性抗体（dsa）导致移植排斥。在这一期的《免疫》杂志中，Zhanzak等人重新审视了间接异位反应性CD4+ T细胞在移植中的作用，并证明免疫优势表位刺激了一小部分T细胞，这些T细胞可以被修剪以防止DSA的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cutting to the chase: Pruning alloreactive T cells

Indirect CD4⁺ T cell allorecognition of donor peptides presented by host MHC class II antigens contributes to transplant rejection in part by eliciting donor-specific antibodies (DSAs). In this issue of Immunity, Zhanzak et al. revisit the role of indirectly alloreactive CD4⁺ T cells in transplantation and demonstrate that immunodominant epitopes stimulate a narrow repertoire of T cells that can be pruned to prevent DSA formation.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.