强化射频消融治疗复发性肝癌经动脉化疗栓塞后:一项利用双内冷灌注电极的前瞻性研究。

Journal of liver cancer Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI:10.17998/jlc.2025.01.25
Sungjun Hwang, Jae Hyun Kim, Sae-Jin Park, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Jeong Min Lee
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引用次数: 0

摘要

背景:射频消融(RFA)被广泛用于治疗经动脉化疗栓塞(TACE)后复发性肝细胞癌(HCC)。然而,治疗后的局部肿瘤进展(LTP)仍然是一个重大挑战。本研究评估了使用双内冷灌注(TICP)电极的盐水灌注双极RFA治疗tace后复发HCC的疗效。方法:在2017年9月至2019年1月期间,前瞻性纳入100例患者,共105例结节(平均直径:1.6±0.5 cm)。双极RFA与TICP电极在超声ct /MR融合引导下进行。主要终点是2年LTP累积发生率。结果:技术成功率为100%,技术有效率为97%。在34.0个月的中位随访期间(范围:3-41个月),估计1年LTP率为13.3%,2年为17.7%。1年和2年的无进展生存率分别为37.8%和27.7%。结论:采用TICP电极的盐水灌注双极RFA治疗TACE术后复发性HCC效果良好,技术成功率高,局部肿瘤控制率有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhanced radiofrequency ablation for recurrent hepatocellular carcinoma post-transarterial chemoembolization: a prospective study utilizing twin internally cooled-perfusion electrodes.

Backgrounds/aims: Radiofrequency ablation (RFA) is widely employed for managing recurrent hepatocellular carcinoma (HCC) following transarterial chemoembolization (TACE). However, local tumor progression (LTP) after treatment remains a significant challenge. This study evaluates the efficacy of saline-perfused bipolar RFA using twin internally cooled-perfusion (TICP) electrodes in managing recurrent HCC post-TACE.

Methods: Between September 2017 and January 2019, 100 patients with 105 nodules (mean diameter, 1.6±0.5 cm) were prospectively enrolled. Bipolar RFA with TICP electrodes was performed under ultrasound-computed tomography/magnetic resonance fusion guidance. The primary outcome was the 2-year cumulative incidence of LTP.

Results: The technical success and technique efficacy rates were 100% and 97%, respectively. During a median follow-up period of 34.0 months (range, 3-41), the estimated LTP rates were 13.3% at 1 year and 17.7% at 2 years. Progression-free survival rates were 37.8% and 27.7% at 1 year and 2 years, respectively.

Conclusions: Saline-perfused bipolar RFA using TICP electrodes demonstrates promising results for recurrent HCC after TACE, achieving high technical success and effective local tumor control rates.

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