纳米颗粒在癌症治疗中的最新进展。

IF 2.8 4区 医学 Q2 ONCOLOGY
Dinesh Kumar Sharma
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引用次数: 0

摘要

纳米技术是帮助研究人员克服药物渗透性和滞留效应的重要因素。本文讨论了不同的纳米颗粒,如金属纳米颗粒、碳纳米管(CNTs)和细胞外囊泡(ev)如何改变癌症的治疗和诊断。CNTs具有光热特性,可在与化疗配合时实现协同效应,而ev具有生物相容性和免疫逃逸能力,可实现有效的药物运输。由于其特殊的光学和磁性,金属纳米颗粒在成像和靶向药物管理中是必不可少的。与传统治疗方法相比,这些纳米颗粒提高了生物利用度,降低了全身毒性,提高了治疗效果。尽管调查增加了,获得许可的纳米药物的数量仍然相对较高。使用纳米载体靶向给药需要更多的研究,以尽量减少蛋白质冠的屏蔽影响,增加渗透性和滞留作用,降低毒性以改善临床翻译。这项研究的重点是利用纳米颗粒靶向不同癌细胞的新方法和最先进的癌症治疗方法。它还强调了基于纳米粒子的癌症疗法相对于传统疗法的优势、它们的困难和未来的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent advancements in nanoparticles for cancer treatment.

Nanotechnology is a significant factor that has assisted researchers in overcoming medications' permeability and retention effects. This article discusses how different nanoparticles, such as metallic nanoparticles, carbon nanotubes (CNTs), and extracellular vesicles (EVs), are transforming cancer treatments and diagnosis. While CNTs provide photothermal qualities that enable synergistic effects when paired with chemotherapy, EVs provide biocompatibility and immune evasion, enabling effective drug transport. Because of their special optical and magnetic characteristics, metallic nanoparticles are essential for imaging and targeted medication administration. When compared to traditional treatments, these nanoparticles improve bioavailability, decrease systemic toxicity, and increase therapeutic efficacy. Despite increased investigations, the number of licensed nano-drugs has remained relatively high. More investigation is required into targeted drug delivery using nanocarriers to minimize the shielding impact of the protein corona, increase permeability and retention effects, and reduce toxicity to improve clinical translation. This study focuses on novel approaches and state-of-the-art cancer therapies using nanoparticles that target different cancer cells. It also emphasized the advantages of nanoparticle-based cancer therapies over conventional ones, their difficulties, and future promises.

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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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