杜氏肌营养不良伴极度消瘦1例及基于胱抑素c的eGFR与菊粉清除率的差异。

IF 1.1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2025-08-15 Epub Date: 2025-02-08 DOI:10.2169/internalmedicine.4920-24

Makiko Takeyasu, Naoki Sawa, Keiichi Sumida, Yuki Oba, Hiroki Mizuno, Shigekazu Kurihara, Noriko Inoue, Akinari Sekine, Kiho Tanaka, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Takehiko Wada, Izumi Sugimoto, Yoshifumi Ubara

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引用次数: 0

摘要

我们描述的情况下，25岁的男性杜氏肌营养不良症和急性肾损伤谁是接受机械通气。在肾功能恢复期间，使用基于肌酐、胱抑素C和菊粉水平的公式评估患者估计的肾小球滤过率（eGFR）。基于肌酐的eGFR在整个研究期间都非常高。基于胱抑素c的eGFR也高于菊粉清除率。这些发现表明，除了肌肉量减少外，在脂肪量极度减少的患者中，基于胱抑素c的eGFR也可能超过菊粉清除率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Duchenne Muscular Dystrophy with Extreme Emaciation and a Discrepancy between Cystatin C-based eGFR and Inulin Clearance.

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Duchenne Muscular Dystrophy with Extreme Emaciation and a Discrepancy between Cystatin C-based eGFR and Inulin Clearance.

We describe the case of a 25-year-old male with Duchenne muscular dystrophy and acute kidney injury who was receiving mechanical ventilation. The patient's estimated glomerular filtration rate (eGFR) was assessed using formulas based on creatinine, cystatin C, and inulin levels over time during the recovery of his renal function. The creatinine-based eGFR was extremely high throughout the study period. The cystatin C-based eGFR was also higher than the inulin clearance. These findings suggest that cystatin C-based eGFR may also exceed inulin clearance in patients with an extremely reduced fat mass, in addition to a reduced muscle mass.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.