The Value of IL-6, D-D, and White Blood Cell Tests in the Diagnosis of Severe Pneumonia.

Introduction: This paper aimed to unravel the value of interleukin-6 (IL-6), D-dimer (D-D), and white blood cell (WBC) tests in the diagnosis of severe pneumonia.

Methods: Sixty cases of pneumonia patients were selected as the observation group, which were divided into the non-severe group (35 cases) and the severe group (25 cases) following the severity of the disease, and 50 health check-up participants in the same time period were chosen as the control group. The general information of the control and the observation groups was compared; IL-6, D-D, and WBC levels were observed in the non-severe and the severe groups. Logistic multivariate regression analysis was implemented to analyze the independent factors predicting severe pneumonia, and the receiver operating characteristic (ROC) curve was adopted to observe the diagnostic value of IL-6, D-D, and WBC for severe pneumonia.

Results: There was no difference in general information between the observation and the control groups, and between the severe and the non-severe groups (p > 0.05); IL-6, D-D, and WBC levels in the severe group were markedly higher relative to the non-severe group; the multivariate logistic regression analysis showed that IL-6 (p < 0.05, 95% CI: 1.076-1.443) and D-D (p < 0.05, 95% CI: 1.367-66.079) were independent factors predicting severe pneumonia; the ROC curve analysis revealed that the area under the curves (AUCs) of IL-6, D-D, and WBC were 0.957, 0.874, and 0.639, respectively; the combined AUC of the three was 0.978, demonstrating that the predictive value of the combined test was higher than that of the single test.

Conclusion: IL-6, D-D, and WBC are significantly elevated in severe pneumonia and have predictive value in severe pneumonia.