基于NIR-II成像检测无外周动脉疾病的2型糖尿病患者下肢灌注早期变化

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-03-01 Epub Date: 2025-02-08 DOI:10.1016/j.diabres.2025.112038

Yijie Ning , Jie Hu , Yikun Zhu , Wei Tang , Sheng Yan , Haifeng Li , Zeyu Zhang , Chuanlong Lu , Keyao Ren , Peilu Shi , Tian Yao , Qian Wang , Yan Zhao , Tingting Gao , Ruijing Zhang , Honglin Dong

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引用次数: 0

摘要

2型糖尿病（T2D）加重了下肢动脉斑块的形成，这是下肢外周动脉疾病（PAD）的早期阶段。第二近红外区（NIR-II）成像是一种新兴的高灵敏度检测灌注水平的技术。本研究探讨了NIR-II成像在无PAD的T2D患者下肢动脉斑块灌注改变识别中的价值。方法将120例T2D患者分为斑块组和非斑块组，采用吲哚菁绿（ICG）对其进行snir - ii成像。分析两组患者的NIR-II参数和临床特征，以确定下肢动脉斑块的重要预测因素。结果两组NIR-II的6项影像学指标（T起始、t1 /2、Tmax、入息率、出息率、出息率）及诊断效能差异均有统计学意义。三个NIR-II参数（T起始、退出和退出率）和两个临床特征（年龄和性别）被确定为下肢动脉斑块的独立预测因子。nomogram显示NIR-II参数与临床特征相结合的模型具有较高的诊断效果。结论nir - ii成像可有效检测T2D患者早期灌注变化，对PAD高危人群的预诊断有较大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

NIR-II imaging-based detection of early changes in lower limb perfusion in type 2 diabetes patients without peripheral artery disease

查看原文本刊更多论文

NIR-II imaging-based detection of early changes in lower limb perfusion in type 2 diabetes patients without peripheral artery disease

Aims

The formation of lower limb arterial plaques, exacerbated by type 2 diabetes (T2D), represents an early stage of lower limb peripheral artery disease (PAD). Second near-infrared region (NIR-II) imaging is an emerging technique with high sensitivity for detecting perfusion levels. This study explores the value of NIR-II imaging in identifying perfusion changes due to lower extremity arterial plaques in T2D patients without PAD.

Methods

NIR-II imaging with indocyanine green (ICG) was conducted on 120 T2D patients, who were categorized into two groups: plaque and non-plaque. NIR-II parameters and clinical characteristics were analyzed between the two groups to identify significant predictors of lower extremity arterial plaques.

Results

Six NIR-II imaging parameters (T start, T 1/2, Tmax, Ingress rate, Egress, and Egress rate) showed significant differences and diagnostic efficacy between the two groups. Three NIR-II parameters (T start, Egress, and Egress rate) and two clinical characteristics (age and sex) were identified as independent predictors of lower limb artery plaques. The nomogram showed that a combined model with NIR-II parameters and clinical characteristics exhibited higher diagnostic efficacy.

Conclusion

NIR-II imaging can effectively detect early perfusion changes in T2D patients, showing great potential for pre-diagnosis of individuals at high risk for PAD.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.