早期多发性硬化症活动中的内分泌干扰物

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2025-02-07 DOI:10.1016/j.jneuroim.2025.578546

Tzu-Ying Chuang , Brenna A. LaBarre , Osman Corbali , Brian C. Healy , Shrishti Saxena , Talia B. Feldman , Eunnindy Sanon , Taylor J. Saraceno , Tanuja Chitnis

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引用次数: 0

摘要

背景与目的流行病学数据显示，多发性硬化症（MS）的患病率和MS患者的男女性别比随着时间的推移而增加。内分泌干扰物（EDCs）普遍存在，并越来越多地认识到其对雌激素信号的影响。本研究旨在确定新诊断的女性MS患者中EDC水平与疾病严重程度之间是否存在关联。方法：本探索性观察队列研究通过布里格姆MS中心的书面知情同意，招募年龄在18-60岁的女性患者。入组标准包括在过去5年内诊断为多发性硬化症，并完成关于潜在EDC暴露的问卷调查。排除标准为30天内静脉注射类固醇。收集过程和材料的设计可以避免EDC污染。尿液样本由NSF International （Ann Arbor, Michigan）分析。主要结果测量是MRI参数和临床疾病活动性，包括调整MS治疗类型的多变量分析。分析采用Spearman相关检验，组间比较采用单因素方差分析。结果：68例MS患者入组。在邻苯二甲酸盐中，mEOHP与T2病变体积随时间呈负相关（R值= - 0.522，p值= 0.002，经Bonferroni调整p = 0.03）。对于酚类物质，三氯卡班与奶酪消费呈负相关（R值= - 0.402,p = 0.001， Bonferroni调整p = 0.012）。EDCs与疾病活动或人口统计学因素之间没有关联，与家用塑料暴露也没有显著相关性。结论本探索性研究发现三氯卡班与奶酪消费呈负相关。纵向上，邻苯二甲酸酯代谢物mEOHP随时间与T2病变体积呈负相关。暴露于EDCs可能影响MS的早期病程，扩大研究工作是有必要的。

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Endocrine disrupting chemicals in early MS disease activity

Background and objectives

Epidemiological data shows that the prevalence of multiple sclerosis (MS) and the female-to-male sex ratio among MS patients are increasing over time. Endocrine disrupting chemicals (EDCs) are ubiquitous and increasingly recognized for effects on estrogen signaling. This study aimed to determine whether there was an association between EDC levels and disease severity in newly diagnosed, female MS patients.

Methods

This exploratory observational cohort study enrolled female patients, ages 18–60, via written informed consent from the Brigham MS Center. Enrollment criteria included diagnosis with MS within the past 5 years and completion of a questionnaire about potential EDC exposures. Exclusion criteria were intravenous steroids in the past 30 days. Collection processes and materials were designed to avoid EDC contamination. Urine samples were analyzed by NSF International (Ann Arbor, Michigan).

Primary outcome measures were MRI parameters and clinical disease activity, including multivariable analysis adjusting for MS treatment types. Spearman correlation test was used for analysis and between group comparisons were conducted with one-way ANOVA.

Results: 68 patients with MS were enrolled. In the phthalates, mEOHP was negatively correlated with T2 lesion volume over time (R value = −0.522, p-value = 0.002, Bonferroni adjusted p = 0.03). For the phenols, triclocarban was negatively associated with cheese consumption (R value = −0.402, p = 0.001, Bonferroni adjusted p = 0.012) There was no association between EDCs and disease activity or demographic factors, nor significant correlation with exposure to household plastics.

Conclusion

This exploratory study identified a negative correlation between triclocarban and cheese consumption. Longitudinally, phthalate metabolite mEOHP was negatively correlated with T2 lesion volume over time. Exposure to EDCs may affect the early disease course in MS, and expansion of research efforts is warranted.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.