热休克蛋白在辐射诱导效应中的作用及其潜在临床应用

Q1 Health Professions
Ying Xu, Wentao Hu, Guangming Zhou
{"title":"热休克蛋白在辐射诱导效应中的作用及其潜在临床应用","authors":"Ying Xu,&nbsp;Wentao Hu,&nbsp;Guangming Zhou","doi":"10.1016/j.radmp.2024.11.002","DOIUrl":null,"url":null,"abstract":"<div><div>Heat shock protein (HSP), as an intracellular chaperone, is significantly upregulated when cells are exposed to radiation and other stress environments, playing an important role in cell self-protection. This phenomenon not only provides a mechanism for normal tissues to resist radiation damage, but also provides a strategy for cancer cells to reduce their sensitivity to radiation and escape treatment. More research is needed to clarify the specific mechanism of HSP in radiotherapy and how to better use its biological effects for clinical individualized treatment. This paper reviews the biological effects of HSP under radiation and the latest research progress of combined radiation and HSP inhibitors or hyperthermia, in the hope of having a more comprehensive understanding of its mechanism in physiological processes such as cell survival, apoptosis, inflammation, immune response, as well as radiation response, which will help to enhance the therapeutic effect and to provide more effective and safer radiotherapy for cancer patients in the future.</div></div>","PeriodicalId":34051,"journal":{"name":"Radiation Medicine and Protection","volume":"6 1","pages":"Pages 51-60"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of heat shock protein in radiation-induced effect and related potential clinical application\",\"authors\":\"Ying Xu,&nbsp;Wentao Hu,&nbsp;Guangming Zhou\",\"doi\":\"10.1016/j.radmp.2024.11.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Heat shock protein (HSP), as an intracellular chaperone, is significantly upregulated when cells are exposed to radiation and other stress environments, playing an important role in cell self-protection. This phenomenon not only provides a mechanism for normal tissues to resist radiation damage, but also provides a strategy for cancer cells to reduce their sensitivity to radiation and escape treatment. More research is needed to clarify the specific mechanism of HSP in radiotherapy and how to better use its biological effects for clinical individualized treatment. This paper reviews the biological effects of HSP under radiation and the latest research progress of combined radiation and HSP inhibitors or hyperthermia, in the hope of having a more comprehensive understanding of its mechanism in physiological processes such as cell survival, apoptosis, inflammation, immune response, as well as radiation response, which will help to enhance the therapeutic effect and to provide more effective and safer radiotherapy for cancer patients in the future.</div></div>\",\"PeriodicalId\":34051,\"journal\":{\"name\":\"Radiation Medicine and Protection\",\"volume\":\"6 1\",\"pages\":\"Pages 51-60\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiation Medicine and Protection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666555724001175\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Health Professions\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Medicine and Protection","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666555724001175","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Health Professions","Score":null,"Total":0}
引用次数: 0

摘要

热休克蛋白(Heat shock protein, HSP)作为细胞内的一种伴侣蛋白,在细胞暴露于辐射等应激环境时显著上调,在细胞自我保护中发挥重要作用。这一现象不仅为正常组织抵抗辐射损伤提供了机制,也为癌细胞降低对辐射的敏感性和逃避治疗提供了策略。HSP在放疗中的具体作用机制以及如何更好地利用其生物学效应进行临床个体化治疗还有待进一步研究。本文综述了放射作用下HSP的生物学效应,以及放射联合HSP抑制剂或热疗的最新研究进展,希望能更全面地了解其在细胞存活、凋亡、炎症、免疫反应、辐射反应等生理过程中的机制,有助于提高治疗效果,为今后癌症患者提供更有效、更安全的放疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of heat shock protein in radiation-induced effect and related potential clinical application
Heat shock protein (HSP), as an intracellular chaperone, is significantly upregulated when cells are exposed to radiation and other stress environments, playing an important role in cell self-protection. This phenomenon not only provides a mechanism for normal tissues to resist radiation damage, but also provides a strategy for cancer cells to reduce their sensitivity to radiation and escape treatment. More research is needed to clarify the specific mechanism of HSP in radiotherapy and how to better use its biological effects for clinical individualized treatment. This paper reviews the biological effects of HSP under radiation and the latest research progress of combined radiation and HSP inhibitors or hyperthermia, in the hope of having a more comprehensive understanding of its mechanism in physiological processes such as cell survival, apoptosis, inflammation, immune response, as well as radiation response, which will help to enhance the therapeutic effect and to provide more effective and safer radiotherapy for cancer patients in the future.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Radiation Medicine and Protection
Radiation Medicine and Protection Health Professions-Emergency Medical Services
CiteScore
2.10
自引率
0.00%
发文量
0
审稿时长
103 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信