老年结肠癌患者的免疫变化和康复相关因素：一项试点试验

IF 3 3区医学 Q3 GERIATRICS & GERONTOLOGY

Journal of geriatric oncology Pub Date : 2025-02-10 DOI:10.1016/j.jgo.2025.102200

Byeo Lee Lim , Young Il Kim , Jong Lyul Lee , Chan Wook Kim , Yong Sik Yoon , Yousun Ko , Kyung Won Kim , In Ja Park

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引用次数: 0

摘要

老年结肠癌患者的免疫功能与年轻患者不同。具体来说，对术后恢复和免疫的关注促使了老年结肠癌患者个性化治疗方案的发展。本研究旨在评估≥70岁和≥70岁患者在免疫因子相关参数和术后恢复方面的差异。70年。材料和方法本试点研究纳入了2023年9月至2024年2月在韩国首尔牙山医疗中心接受结肠癌手术切除的75例患者。患者分为两个年龄组：≥70岁和<；70年。分析与康复相关的临床病理特征，以及康复与免疫因素、临床特征之间的关系。EuroQol-5 Dimensions-3问卷得分，反映患者的主观观点，也在两组之间进行比较。结果≥70岁组29例，≥70岁组46例。≥70岁组术前（6.71 vs. 4.27, P = 0.04）和术后第21天（POD#21） IL-6水平均显著高于≥70岁组（13.49 vs. 2.94, P = 0.03）。在所有时间点上，≥70岁组的平均NK细胞计数始终较高：术前(24.54比13.87,P <；0.001), POD#3 (24.32 vs. 15.39, P <；0.001), POD#21 (33.04 vs. 22.47, P <；0.001)。虽然≥70岁组中更大比例的患者术前EQ-5D水平低于平均水平，但差异无统计学意义（20.7%比17.4%,P = 0.96）。免疫因素，如IL-6水平和自然杀伤细胞的数量，在≥70岁的患者中没有减少。此外，该组术后恢复时间不延长。

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Immunological changes and recovery-related factors in older patients with colon cancer: A pilot trial

Introduction

Immunity in older patients with colon cancer differs from that in younger patients. Specifically, concerns regarding postoperative recovery and immunity have prompted the development of personalized treatment options for older patients with colon cancer. This study aimed to assess the differences in immunological factor-related parameters and postoperative recovery between patients aged ≥70 years and < 70 years.

Material and Methods

This pilot study included 75 patients who underwent surgical resection for colon cancer between September 2023 and February 2024 at Asan Medical Center, Seoul, Korea. Patients were divided into two age groups: ≥70 years and < 70 years.

The clinicopathological features associated with recovery, and the association among recovery, immunological factors, and clinical characteristics were analyzed. The EuroQol-5 Dimensions-3 questionnaire scores, which reflect the subjective perspectives of patients, were also compared between the two groups.

Results

There were 29 patients in the ≥70 years group and 46 patients in the <70 years group. The ≥70 years group exhibited significantly higher IL-6 levels than the <70 years group both preoperatively (6.71 vs. 4.27, P = 0.04) and on postoperative day 21 (POD#21) (13.49 vs. 2.94, P = 0.03). The average NK cell counts were consistently higher in the ≥70 years group across all time points: preoperatively (24.54 vs. 13.87, P < 0.001), POD#3 (24.32 vs. 15.39, P < 0.001), and POD#21 (33.04 vs. 22.47, P < 0.001). While a greater proportion of patients in the ≥70 years group had below-average preoperative EQ-5D levels, this difference was not statistically significant (20.7 % vs. 17.4 %, P = 0.96).

Discussion

Immunological factors, such as IL-6 levels and the number of natural killer cells, did not diminish in patients aged ≥70 years. Furthermore, postoperative recovery was not prolonged in this group.

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来源期刊

Journal of geriatric oncology ONCOLOGY-GERIATRICS & GERONTOLOGY

CiteScore

5.30

自引率

10.00%

发文量

379

审稿时长

80 days

期刊介绍： The Journal of Geriatric Oncology is an international, multidisciplinary journal which is focused on advancing research in the treatment and survivorship issues of older adults with cancer, as well as literature relevant to education and policy development in geriatric oncology. The journal welcomes the submission of manuscripts in the following categories: • Original research articles • Review articles • Clinical trials • Education and training articles • Short communications • Perspectives • Meeting reports • Letters to the Editor.