盐酸胍：水生环境下多组分合成苯二氮卓类化合物的绿色有机催化剂

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-02-01 DOI:10.1080/00397911.2025.2457439

Omkar C. Dongare , Pradeep U. Yadav , Yatin U. Gadkari

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引用次数: 0

摘要

采用催化量的盐酸胍在水条件下合成1,5-苯二氮卓衍生物，建立了一种高效、环保的合成方法。通过不同取代芳基醛与邻苯二胺和二美酮的结合，得到了高收率的所需化合物。该方案具有几个优点，包括快速反应时间，使用更环保的溶剂，简单的后续处理程序和简单的净化过程，确保能源效率和多功能性。此外，催化剂可以循环使用4-5次而不影响总收率，这增加了该方法的总体优点。此外，绿色化学指标，如EcoScale， E-Factor和过程质量强度（PMI）被用来全面评估过程的环境影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Guanidine HCl: a green organo-catalyst for effective multicomponent synthesis of benzodiazepine derivatives under aquatic environment

An efficient and environmentally friendly methodology has been developed for the synthesis of 1,5-benzodiazepine derivatives, employing catalytic amounts of guanidine hydrochloride in aqueous conditions. The desired compounds were obtained with high yields by combining variously substituted aryl aldehydes with o-phenylene diamine and dimedone. The protocol offers several advantages, including a rapid reaction time, the use of greener solvents, simple workup procedures, and an uncomplicated purification process, ensuring energy efficiency and versatility. Also, the catalyst can be recycled up to 4-5 cycles without compromising the overall yield, adding to the overall merit of this method. Furthermore, green chemistry metrics such as EcoScale, E-Factor, and Process Mass Intensity (PMI) were employed to evaluate the environmental impact of the process thoroughly.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.