从菊花中提取的一种新的酚类苷

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-02-10 DOI:10.1016/j.phytol.2025.01.1004

Wuttichai Jaidee , Narawadee Rujanapun , Thidarat Duangyod , Subhadip Banerjee , Tharakorn Maneerat , Sarot Cheenpracha , Surat Laphookhieo , Passakorn Teerapongpisan , Salfarina Ramli , Rawiwan Charoensup

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引用次数: 0

摘要

对采自泰国的Handroanthus chrysanthus花的甲醇提取物进行植物化学研究，分离出一种新的酚类苷parmentin C(1)，以及7种已知化合物（2-8）。其中酚苷类化合物1 ~ 5为首次从该属植物中分离得到。通过广泛的光谱分析和与文献中报道的核磁共振数据的比较，确定了这些结构。对分离得到的化合物对肺癌（A549）和结肠癌（SW480）细胞的抗癌活性和α-葡萄糖苷酶抑制活性进行了评价。体外实验结果表明，从菊花中分离得到的化合物具有药理潜力。

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Parmentin C, a new phenolic glycoside from Handroanthus chrysanthus flowers

Phytochemical studies of the methanol extract of Handroanthus chrysanthus flowers, collected in Thailand, led to the isolation of a new phenolic glycoside, parmentin C (1), along with seven known compounds (2–8). Among them, the phenolic glycoside compounds 1–5 were first isolated from the Handroanthus genus. The structures were determined by extensive spectroscopic analysis and comparison of their NMR data to those reported in the literature. The anticancer activity of the isolated compounds against lung cancer (A549) and colon cancer (SW480) cells and α-glucosidase inhibition activity were evaluated. Results derived from in vitro experiments suggest the pharmacological potential of the isolated compound from Handroanthus chrysanthus flowers.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.