代谢物信号传导促进免疫抑制细胞向肿瘤募集

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-02-10 DOI:10.1038/s41590-025-02094-x

引用次数: 0

摘要

代谢物感应G蛋白偶联受体在癌症中作为连接代谢和免疫的关键信号枢纽。本研究表明，结直肠肿瘤细胞中乳酸受体HCAR1的激活导致免疫抑制性PMN-MDSCs向肿瘤募集，从而损害抗肿瘤免疫并降低免疫治疗的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors

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Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors

Metabolite-sensing G protein-coupled receptors act as critical signaling hubs that connect metabolism to immunity in cancer. Here we show that activation of the lactate receptor HCAR1 in colorectal tumor cells leads to the recruitment of immunosuppressive PMN-MDSCs to tumors, thereby impairing anti-tumor immunity and diminishing the effectiveness of immunotherapies.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.