前周屈光性青光眼24-2C视野测试附加点的评价。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-06 DOI:10.1016/j.pdpdt.2025.104513

Gökhan Çelik , Tuncay Karaçocuk , Furkan Çiftci

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引用次数: 0

摘要

背景：早期发现和预防青光眼进展至关重要。然而，早期视野（VF）变化的研究，特别是使用24-2C VF测试的研究，是有限的。评估2C的附加点可能有助于在早期发现青光眼，从而及时干预。围周前青光眼（PPG）的特征是结构损伤，在标准测试中没有明显的VF损失。评估视网膜神经纤维层（RNFL）和黄斑神经节细胞复合体（mGCC）厚度的变化是有价值的，但探索这些结构变化与功能缺陷的关系是至关重要的。目的：本研究关注24-2C测试加分的平均值，了解其与PPG结构措施的相关性。材料与方法：本研究纳入59例PPG患者和36例健康人。所有患者均接受了乳头周围和黄斑光学相干断层扫描（OCT） (Nidek RS-3000 Advance；Nidek、日本)。使用乳头周围OCT评估RNFL厚度，使用黄斑OCT青光眼模块评估mGCC厚度。使用24-2C SITA Faster VF Humphrey field Analyser III Model 850 (HFAIII；蔡司医疗，都柏林，CA， USA)。对结构参数和功能参数之间的关系进行统计评价。结果：PPG组RNFL和mGCC厚度值明显低于健康组。两组间MD、PSD、VFI无显著差异。对于AAP-2C， PPG组的敏感性明显低于健康个体。AAP-2C与mGCC厚度呈正相关（p = 0.003,r = 0.385）。然而，RNFL和mGCC厚度值与MD、PSD和VFI没有统计学意义上的相关性。结论：虽然PPG患者的VF未见青光眼改变，但这些患者对附加点的敏感性降低。24-2C VF测试中附加点的敏感度降低可能反映了早期黄斑功能改变，这些改变与围视期前的结构损伤有关。

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Evaluation of additional points in the 24-2C visual field test in pre-perimetric glaucoma

Background

Early detection and prevention of glaucoma progression are critical. However, studies of early visual field (VF) changes, particularly those using the 24-2C VF test, are limited. Evaluation of additional points in 2C may help identify glaucoma at an early stage, enabling timely intervention. Pre-perimetric glaucoma (PPG) is characterised by structural damage without noticeable VF loss in standard tests. Assessments of changes in retinal nerve fibre layer (RNFL) and macular ganglion cell complex (mGCC) thickness are valuable, but exploring how these structural changes are related to functional deficits is crucial.

Objective

This study focused on the average of the additional points in the 24-2C test to understand their correlation with structural measures in the PPG.

Material and method

This study included 59 patients with PPG and 36 healthy individuals. All the patients underwent peripapillary and macular optical coherence tomography (OCT) (Nidek RS-3000 Advance; Nidek, Japan). RNFL thickness was evaluated using peripapillary OCT, and mGCC thickness was evaluated using the macular OCT glaucoma module. The mean deviation (MD), pattern standard deviation (PSD), visual field index (VFI), and average of additional points in the 2C (AAP-2C) were evaluated using the 24-2C SITA Faster VF Humphrey Field Analyser III Model 850 (HFAIII; Zeiss Meditec, Dublin, CA, USA). The relationship between structural and functional parameters was statistically evaluated.

Results

The PPG group showed significantly lower RNFL and mGCC thickness values than the healthy group. The MD, PSD, and VFI did not differ significantly between the groups. For AAP-2C, the PPG group showed significantly lower sensitivity than healthy individuals. A statistically significant positive correlation between was observed between AAP-2C and mGCC thickness (p = 0.003, r = 0.385). However, the RNFL and mGCC thickness values showed no statistically significant correlations with the MD, PSD, and VFI.

Conclusion

Although no glaucomatous change was observed in the VF in patients with PPG, these patients showed reduced sensitivity of the additional points. The reduced sensitivity of the additional points in the 24-2C VF test may reflect early macular functional alterations that correlate with structural damage during the pre-perimetric period.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.