大豆异黄酮治疗骨质疏松的潜在机制:以骨代谢和氧化应激为重点。

IF 6.1 2区 医学 Q1 CHEMISTRY, MEDICINAL
Phytotherapy Research Pub Date : 2025-03-01 Epub Date: 2025-02-08 DOI:10.1002/ptr.8451
Yuanyuan Zhou, Zhan Su, Gang Liu, Siwang Hu, Jiang Chang
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引用次数: 0

摘要

骨质疏松症分为原发性和继发性。原发性骨质疏松症可能由绝经后妇女雌激素缺乏、老年人骨重塑不平衡或青少年型骨发育不平衡引起。继发性骨质疏松症可由长期糖皮质激素治疗、慢性肾脏疾病(CKD)、雌激素剥夺、氧化应激、糖尿病和肥胖等因素引起。本文就大豆异黄酮治疗骨质疏松症的潜力进行综述。在细胞水平上,大豆异黄酮作为天然植物提取物和植物雌激素,对成骨细胞的发生和分化、破骨细胞的发生、破骨细胞矿化和骨髓间充质间质细胞的分化至关重要。它们还通过调节细胞外钙和维生素D水平来维持钙稳态。在氧化应激方面,大豆异黄酮减轻内质网和线粒体的氧化应激,从而调节细胞衰老、自噬和骨重塑过程。此外,大豆异黄酮可以缓解CKD相关症状,抑制糖皮质激素分泌,直接或间接有利于骨质疏松症的治疗。总的来说,大豆异黄酮有可能通过增强骨骼健康、调节新陈代谢和减轻氧化应激来治疗骨质疏松症。未来的研究应探索大豆异黄酮作为植物雌激素治疗骨质疏松症的潜力。这一探索应侧重于阐明安全性,识别潜在的副作用,确定最佳给药方案,并制定减轻任何不良反应的策略。此外,为了准确评价大豆异黄酮对骨质疏松症的实际治疗效果,还需要进一步开展大规模、多中心的人体临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Potential Mechanism of Soy Isoflavones in Treating Osteoporosis: Focusing on Bone Metabolism and Oxidative Stress.

Osteoporosis is divided into primary and secondary types. Primary osteoporosis may result from estrogen deficiency in postmenopausal women, imbalanced bone remodeling in the elderly, or imbalanced adolescent-type bone development. Secondary osteoporosis can be caused by factors like long-term glucocorticoid treatment, chronic kidney disease (CKD), estrogen deprivation, oxidative stress, diabetes, and obesity. This review focuses on the therapeutic potential of soy isoflavones for osteoporosis. At the cellular level, soy isoflavones, as natural plant extracts and phytoestrogens, are crucial for osteoblastogenesis and differentiation, osteoclastogenesis, osteoclast mineralization, and bone marrow mesenchymal stromal cell differentiation. They also maintain calcium homeostasis by regulating extracellular calcium and vitamin D levels. In terms of oxidative stress, soy isoflavones mitigate it in the endoplasmic reticulum and mitochondria, thus regulating cellular senescence, autophagy, and bone remodeling processes. Moreover, soy isoflavones can relieve symptoms related to CKD and inhibit glucocorticoid secretion, which directly or indirectly benefits the treatment of osteoporosis. Overall, soy isoflavones have the potential to treat osteoporosis by enhancing bone health, regulating metabolism, and alleviating oxidative stress. Future research should explore the potential of soy isoflavones as phytoestrogens for treating osteoporosis. This exploration should focus on clarifying the safety, identifying potential side effects, determining the optimal dosage regimen, and developing strategies to mitigate any adverse reactions. In addition, further large-scale, multicenter human clinical trials are necessary to accurately evaluate the actual therapeutic effect of soy isoflavones on osteoporosis.

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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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