七氟醚减轻老龄小鼠肠缺血再灌注损伤。

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Medical Gas Research Pub Date : 2025-09-01 Epub Date: 2025-02-08 DOI:10.4103/mgr.MEDGASRES-D-24-00033
Yujing Cai, Yanan Wu, Zhimin Guo, Yingxian Ye, Yi Zhu, Lanqi Wen, Haifeng Li, Xue Han, Daili Chen, Xuefei Duan
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引用次数: 0

摘要

七氟醚是围手术期广泛使用的吸入麻醉剂。最近的研究表明,七氟醚具有肠道保护作用,但其机制尚不清楚。为探讨七氟醚对肠道缺血再灌注损伤的作用机制,建立小鼠肠道缺血再灌注损伤模型。首先,比较老年小鼠和年轻小鼠的肠缺血再灌注损伤。结果表明,肠缺血再灌注损伤引起病理性肠损伤,破坏肠黏膜屏障。老龄小鼠肠道缺血再灌注损伤较幼龄小鼠更为严重,因此存活率较低。随后,老龄小鼠吸入七氟醚。七氟醚可减轻老龄小鼠肠黏膜的病理性损伤,修复肠黏膜屏障功能,从而提高肠黏膜缺氧诱导因子-1α水平,提高老龄小鼠的存活率。然而,术前给予缺氧诱导因子-1α抑制剂BAY87-2243可抵消七氟醚的肠保护作用,降低缺氧诱导因子-1α下游抗氧化酶血红素加氧酶-1的表达水平。我们的研究结果提示,七氟醚通过激活缺氧诱导因子-1α/血红素加氧酶-1修复肠道黏膜屏障,减轻老年小鼠肠道缺血再灌注损伤,为治疗老年小鼠肠道缺血再灌注损伤提供了新的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sevoflurane alleviates intestinal ischemia-reperfusion injury in aged mice.

Sevoflurane is a widely used inhalation anesthetic during the perioperative period. Recent studies have suggested that sevoflurane has an enteroprotective effect, but its mechanism is unclear. To explore the mechanism of sevoflurane in intestinal ischemia‒reperfusion injury, an intestinal ischemia‒reperfusion injury mouse model was established. First, intestinal ischemia‒reperfusion injury was compared between aged and young mice. The results showed that intestinal ischemia‒reperfusion injury caused pathological intestinal injury and disrupted the intestinal mucosal barrier. The aged mice had more severe intestinal ischemia‒reperfusion injury than the young mice and therefore had a lower survival rate. The aged mice subsequently received sevoflurane via inhalation. Sevoflurane alleviated the pathological injury to the intestinal mucosa and repaired the function of the intestinal mucosal barrier in aged mice, thus increasing the level of intestinal mucosal hypoxia-inducible factor-1α and improving the survival rate of aged mice. However, preoperative administration of the hypoxia-inducible factor-1α inhibitor BAY87-2243 could counteract the enteroprotective effect of sevoflurane and lower the expression level of heme oxygenase-1, a downstream antioxidant enzyme of hypoxia-inducible factor-1α. Our findings suggest that sevoflurane alleviates intestinal ischemia‒reperfusion injury in aged mice by repairing the intestinal mucosal barrier through the activation of hypoxia-inducible factor-1α/heme oxygenase-1, providing a new target for the treatment of intestinal ischemia‒reperfusion injury in aged mice.

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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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