Florencio Manuel Marín-Martínez, Julian J Arense-Gonzalo, Miriam Artes Artes, Emny Rochell Bobadilla Romero, Victor Garcia Porcel, Mabel Coromoto Suárez-Pineda, Pablo Luis Guzmán Martínez-Valls, Jaime Mendiola
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引用次数: 0
摘要
目的：探讨肛门生殖器距离（AGD）与迟发性性腺功能减退（LOH）风险的关系。方法：在2019年9月至2021年12月期间，前瞻性招募145例因前列腺特异性抗原（PSA）升高或直肠指检异常而转诊进行经直肠前列腺活检的患者。测量了肛门至阴囊基部（AGDas）和肛门至阴茎背端（AGDap）两种AGD变异。测定07.00 ~ 11.00 h空腹时血清总睾酮水平。患者填写老年男性症状（AMS）量表问卷。结果：29%的参与者被诊断为LOH，其AGDap均短于无LOH的男性，AGDap为116.09 mm （9.02 mm）对128.71 mm (10.76 mm)， AGDas为29.70 mm （8.01 mm）对39.93 mm (11.64 mm)；结论：这项工作增加了科学证据，证明agd（胎儿暴露的生物标志物）可以提供一种非侵入性措施来解决LOH，提供了一种潜在的有用的临床工具。
Anogenital distance and the risk of Late-onset hypogonadism.
Objective: to investigate the association between anogenital distance (AGD) and the risk of Late-onset Hypogonadism (LOH).
Methods: We prospectively recruited 145 consecutive patients referred for transrectal prostate biopsy due to prostate-specific antigen (PSA) elevation or abnormal digital rectal examination, between September 2019 and December 2021. Two variants of AGD, anus to scrotum base (AGDas) and anus to dorsal insertion of penis (AGDap) were measured. Serum total testosterone levels in fasting conditions between 07.00 and 11.00 h were determined. Patients filled out the Aging Males' Symptoms (AMS) scale questionnaire.
Results: LOH was diagnosed in 29% of the participants and presented both AGDs shorter than men without LOH, with an AGDap of 116.09 mm (9.02 mm) versus 128.71 (10.76), and an AGDas 29.70 (8.01) versus 39.93 (11.64); both p < 0.05. ANCOVA test showed a significant association between the presence of LOH and both AGD measurements. Besides, AGD measurements presented adequate accuracy for the diagnosis of LOH.
Conclusions: This work adds to the scientific evidence that AGD-a biomarker of fetal exposure-could provide a non-invasive measure to address LOH, providing a potential useful clinical tool.
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