Saima Bibi, Muhammad Naeem, Sabine Schipf, Martin Bahls, Marcus Dörr, Nele Friedrich, Matthias Nauck, Robin Bülow, Henry Völzke, Marcello Ricardo Paulista Markus, Till Ittermann
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Multivariable logistic regression models adjusted for confounding were used to analyse associations of standardized body composition markers derived from classic anthropometry, bioelectrical impedance analysis, magnetic resonance imaging as well as inflammatory markers C-reactive protein, white blood cell count, fibrinogen, ferritin and CRP-to-albumin ratio with prevalent T2D.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Body composition markers were more strongly associated with T2D than inflammatory markers. Waist circumference exhibited the strongest association with T2D (female: odds ratio (OR) = 2.55; 95% confidence interval [CI]: 2.17–3.00; male: OR = 2.20; 95% CI: 1.86–2.60). Similarly, body weight (female: 2.07; 1.78-2.41; male: OR = 1.99; 95% CI = 1.71–2.31), waist-to-height ratio (female: OR = 2.39; 95% CI = 2.05–2.77; male: 2.28; 1.92–2.70) and visceral adipose tissue (female: 3.02; 95% CI = 2.11–4.32; male: 1.50; 1.19–1.89) showed strong associations with T2D. Among inflammatory markers, white blood cell count in male and CRP-to-albumin ratio in female exhibit the strongest association with T2D.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Body composition markers seem to be more tightly associated with prevalent T2D compared to inflammatory markers.</p>\n </section>\n </div>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"55 4","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eci.70005","citationCount":"0","resultStr":"{\"title\":\"Body composition markers are more strongly associated with type 2 diabetes than inflammatory markers—Results from the study of health in Pomerania\",\"authors\":\"Saima Bibi, Muhammad Naeem, Sabine Schipf, Martin Bahls, Marcus Dörr, Nele Friedrich, Matthias Nauck, Robin Bülow, Henry Völzke, Marcello Ricardo Paulista Markus, Till Ittermann\",\"doi\":\"10.1111/eci.70005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background and Aims</h3>\\n \\n <p>Evidence links body composition and inflammatory markers with type 2 diabetes (T2D). 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引用次数: 0
摘要
背景和目的：有证据表明身体成分和炎症标志物与2型糖尿病（T2D）有关。然而，来自不同模式的身体成分标记物和与T2D相关的炎症标记物的比较分析仍未被探索。本研究旨在评估和比较身体成分和炎症标志物与T2D的关系。方法：我们纳入了4043名参与者（2081名女性，51.4%），年龄在20-84岁之间，参加了波美拉尼亚基于人群的健康研究。采用校正混杂因素的多变量logistic回归模型分析标准化身体成分标记物与t2dm患病率的相关性，这些标记物来自经典人体测量学、生物电阻抗分析、磁共振成像以及炎症标记物c反应蛋白、白细胞计数、纤维蛋白原、铁蛋白和crp -白蛋白比。结果：体成分标志物与T2D的相关性强于炎症标志物。腰围与T2D的相关性最强(女性：优势比(OR) = 2.55；95%置信区间[CI]: 2.17-3.00；男性：OR = 2.20；95% ci: 1.86-2.60)。同样，体重(女性：2.07；1.78 - -2.41;男性：OR = 1.99；95% CI = 1.71-2.31)，腰高比(女性：OR = 2.39；95% ci = 2.05-2.77；男:2.28;1.92-2.70)和内脏脂肪组织(女性：3.02；95% ci = 2.11-4.32；男:1.50;1.19-1.89)与T2D密切相关。在炎症标志物中，男性白细胞计数和女性crp /白蛋白比与T2D的相关性最强。结论：与炎症标志物相比，身体成分标志物似乎与流行的T2D更紧密相关。
Body composition markers are more strongly associated with type 2 diabetes than inflammatory markers—Results from the study of health in Pomerania
Background and Aims
Evidence links body composition and inflammatory markers with type 2 diabetes (T2D). However, the comparative analysis of body composition markers derived from different modalities and inflammatory markers in relation to T2D remains unexplored. This study aims to evaluate and compare the association of body composition and inflammatory markers with T2D.
Methods
We included 4043 participants (2081 female, 51.4%) aged 20–84 enrolled in the population-based Study of Health in Pomerania. Multivariable logistic regression models adjusted for confounding were used to analyse associations of standardized body composition markers derived from classic anthropometry, bioelectrical impedance analysis, magnetic resonance imaging as well as inflammatory markers C-reactive protein, white blood cell count, fibrinogen, ferritin and CRP-to-albumin ratio with prevalent T2D.
Results
Body composition markers were more strongly associated with T2D than inflammatory markers. Waist circumference exhibited the strongest association with T2D (female: odds ratio (OR) = 2.55; 95% confidence interval [CI]: 2.17–3.00; male: OR = 2.20; 95% CI: 1.86–2.60). Similarly, body weight (female: 2.07; 1.78-2.41; male: OR = 1.99; 95% CI = 1.71–2.31), waist-to-height ratio (female: OR = 2.39; 95% CI = 2.05–2.77; male: 2.28; 1.92–2.70) and visceral adipose tissue (female: 3.02; 95% CI = 2.11–4.32; male: 1.50; 1.19–1.89) showed strong associations with T2D. Among inflammatory markers, white blood cell count in male and CRP-to-albumin ratio in female exhibit the strongest association with T2D.
Conclusions
Body composition markers seem to be more tightly associated with prevalent T2D compared to inflammatory markers.
期刊介绍：
EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.
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