多层电纺丝移植物用于外科修复:仿生生理升主动脉顺应性。

IF 3.1 4区 医学 Q2 BIOPHYSICS
Julia Krammer, Maximilian Pichlmaier, Jan Stana, Christian Hagl, Sven Peterss, Maximilian Grab, Linda Grefen
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引用次数: 0

摘要

市售涤纶(编织聚酯)移植物用于常规开放性手术修复胸主动脉瘤。尽管具有耐久性和生物相容性,这些移植物不能复制主动脉的自然机械特性。因此,该项目的目的是开发一种具有生理主动脉顺应性的创新型移植物。为了实现这一结果,多层管状主动脉移植物是由热塑性聚氨酯静电纺丝制成的。为了降低透气性,添加了明胶涂层。三组(G1-3;N = 5)采用不同的层设计,评估血管移植物的主要力学性能,如缝线保持强度、渗透性、静态和动态顺应性。G3是一种结合静电纺丝和稳定的硅涂层嵌体的材料,用于制造医用级热塑性聚氨酯接枝(Gm;n = 6)。动态顺应性值分别为19.68±11.5%/100 mmHg (50-90 mmHg)、15.18±8.7%/100 mmHg (80-120 mmHg)和14.56±7.4%/100 mmHg (110-150 mmHg)。其顺应性高于涤纶和ePTFE移植,与正常大小的健康人升主动脉的顺应性(约16%/100 mmHg)和猪主动脉的顺应性(14.3%/100 mmHg)相当。静态顺应性测试成功达到350 mmHg。顺应性测试后,未发现移植物直径或移植物层分层发生明显变化。因此,通过将静电纺丝与耐用的嵌体相结合,获得了弹性和可恢复性,从而成为胸主动脉病变开放手术治疗金标准的有希望的替代方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multi-layered electrospun grafts for surgical repair: Biomimicking physiological ascending aortic compliance.

Commercially available Dacron (woven polyester) grafts are used for routine open surgical repair of thoracic aortic aneurysms. Despite durable and biocompatible, these grafts do not reproduce the natural mechanical properties of the aorta. Therefore, the aim of this project was to develop an innovative graft that additionally exhibits physiological aortic compliance. To achieve this result, multi-layered tubular aortic grafts were created by electrospinning of a thermoplastic polyurethane. To reduce permeability, a gelatin-coating was added. Three groups (G1-3; n = 5) with varying layer designs were evaluated regarding the main mechanical properties of vascular grafts such as suture retention strength, permeability and static and dynamic compliance. G3, which combined electrospinning with a stable silicone-coated inlay was chosen for the fabrication of medical grade thermoplastic polyurethane grafts (Gm; n = 6). Dynamic compliance values of 19.68 ± 11.5%/100 mmHg (50-90 mmHg), 15.18 ± 8.7%/100 mmHg (80-120 mmHg) and 14.56 ± 7.4%/100 mmHg (110-150 mmHg) were achieved. The compliance was higher than for Dacron and ePTFE grafts and comparable to the normal sized ascending aorta of around 16%/100 mmHg in a healthy human and porcine aortic compliance of 14.3%/100 mmHg. Static compliance was successfully tested up to 350 mmHg. No significant changes in graft diameter or delaminations of the graft layers were detected after compliance testing. Therefore, by combining electrospinning with a durable inlay, both elasticity and recoverability are obtained, resulting in a promising alternative to the gold-standard in open-surgical treatment of thoracic aortic pathologies.

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来源期刊
Journal of Applied Biomaterials & Functional Materials
Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL
CiteScore
4.40
自引率
4.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics
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