铁（II），锌（II），和镍（II）络合的n -取代酯的l -氨基酸与杂环羧酸作为一种方法制备水溶性形式能够抑制当前甲型流感病毒株的繁殖

IF 1.1 3区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Russian Journal of Coordination Chemistry Pub Date : 2024-12-22 DOI:10.1134/S1070328424601250

T. M. Garaev, I. I. Yudin, N. V. Breslav, T. V. Grebennikova, V. V. Avdeeva, L. V. Goeva, A. V. Golubev, S. E. Nikiforova, E. A. Malinina, N. T. Kuznetsov

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引用次数: 0

摘要

合成了一系列l -氨基酸与各种杂环和芳香羧酸的n -取代酯。为了提高合成化合物的水溶性，它们被用作铁（II）、锌（II）和镍（II）络合的有机配体。在体外测试了所得水溶液对流感病毒A/ iv - orenburg /83/2012(H1N1)pdm09的抗病毒性能。结果表明，与镍和锌配合物相比，铁（II）配合物在实现高水平的病毒繁殖抑制方面最成功。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Fe(II), Zn(II), and Ni(II) Complexation of N-Substituted Esters of L-Amino Acids with Heterocyclic Carboxylic Acids as a Way to Prepare Aqueous-Soluble Forms Capable of Inhibiting the Reproduction of the Current Influenza A Strain

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A series of N-substituted esters of L-amino acids with various heterocyclic and aromatic carboxylic acids were synthesized. To increase the water solubility of the synthesized compounds, they were used as organic ligands in iron(II), zinc(II), and nickel(II) complexation. The antiviral properties of the resulting aqueous solutions were tested against the influenza virus A/IIV-Orenburg/83/2012(H1N1)pdm09 in vitro. It was shown that complexation with iron(II) was the most successful in achieving a high level of viral reproduction suppression compared to nickel and zinc complexes.

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来源期刊

Russian Journal of Coordination Chemistry 化学-无机化学与核化学

CiteScore

2.40

自引率

15.80%

发文量

审稿时长

7.2 months

期刊介绍： Russian Journal of Coordination Chemistry is a journal that publishes reviews, original papers, and short communications on all aspects of theoretical and experimental coordination chemistry. Modern coordination chemistry is an interdisciplinary science that makes a bridge between inorganic, organic, physical, analytical, and biological chemistry.