Qin Wang, Wenwen Hao, Chao Guo, Hui Cao, Beiqi Wang, Xingyang Li, Ruilian Yu, Li Xu, Jing Li
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The regenerative wound healing effects and molecular mechanism of Isaria cicadae Miquel rice fermentation extract
Human skin wounds primarily heal through reparative wound healing without pilosebaceous units or other appendages, rather than regenerative wound healing. Hair follicle (HF) regeneration is a significant challenge for skin wound healing. The effects and underlying mechanisms of Isaria cicadae Miquel rice fermentation extract (IMFRE) remain unclear, although it has anti-inflammatory, antioxidant, and reparative effects on oxidative damage in keratinocytes. We assessed the regenerative wound healing ability of IMFRE and its related molecular mechanisms through experimental validation and network pharmacology analysis. Our findings suggest that IMFRE could be an important potential solution for regenerative wound healing of skin hair follicle by utilizing the Hippo pathway regulatory mechanism.
• IMFRE was found to significantly enhance the wound healing rate of mouse skin.
• CK15 and CD34 were significantly increased by high-dose IMFRE intervention.
• IMFRE could inhibit EGFR, GPCR, and Integrin expression.
期刊介绍：
Applied Microbiology and Biotechnology focusses on prokaryotic or eukaryotic cells, relevant enzymes and proteins; applied genetics and molecular biotechnology; genomics and proteomics; applied microbial and cell physiology; environmental biotechnology; process and products and more. The journal welcomes full-length papers and mini-reviews of new and emerging products, processes and technologies.
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