多苯丙氨酸-黄芩素纳米胶束减少神经细胞凋亡和炎症,增强神经保护和脑卒中后康复

IF 5.4 2区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ling-Kun Zhang, Li Liu, Ziqing Li, Yiquan Zhang, Limin Zhai, Luna Zhang, Chu-Hua Li* and Yan-Qing Guan*, 
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引用次数: 0

摘要

缺血性脑卒中、神经元死亡和炎症给神经保护和康复带来困难。在这项研究中,我们开发并设计了天然乳铁蛋白-聚乙二醇-聚苯丙氨酸-黄黄素纳米胶束(LF-PEG-PPhe-Bai)靶向和减少这些病理过程的能力,如中风后各阶段的神经损伤和认知障碍。由生物相容性材料制成的纳米胶束提高了生物利用度,并有针对性地分布到受损的大脑区域。结果表明,lf - peg - pphee - bai在体外具有明显的抗氧化、抗细胞凋亡和抗炎症活性。同时,lf - peg - pphee - bai在体内可改善2-VO模型小鼠的行为和认知障碍,保护海马神经细胞,减轻脑损伤部位的炎症。综上所述,LF-PEG-PPhe-Bai纳米胶束具有增强脑卒中后神经保护和康复的作用。该技术的发展可能为神经缺血后的修复提供一种新的技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Polyphenylalanine-Baicalein Nanomicelles Reduce Nerve Cell Apoptosis and Inflammation to Enhance Neuroprotection and Poststroke Rehabilitation

Polyphenylalanine-Baicalein Nanomicelles Reduce Nerve Cell Apoptosis and Inflammation to Enhance Neuroprotection and Poststroke Rehabilitation

Cerebral ischemic stroke, neuronal death, and inflammation bring difficulties in neuroprotection and rehabilitation. In this study, we developed and designed the ability of natural lactoferrin-polyethylene glycol-polyphenylalanine-baicalein nanomicelles (LF-PEG-PPhe-Bai) to target and reduce these pathological processes, such as neurological damage and cognitive impairment in the stages of poststroke. Nanomicelles made from biocompatible materials have improved bioavailability and targeted distribution to afflicted brain areas. The results showed that LF-PEG-PPhe-Bai greatly improved the antioxidation, antiapoptosis, and anti-inflammation activity in vitro. Meanwhile, LF-PEG-PPhe-Bai improved the behavioral and cognitive impairment of 2-VO model mice, protected nerve cells in the hippocampus, and reduced inflammation at the brain injury site in vivo. In conclusion, LF-PEG-PPhe-Bai nanomicelles are employed for enhancing neuroprotection and poststroke rehabilitation. The development of this technology might provide a new technique for neural repair after ischemia in the future.

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来源期刊
Biomacromolecules
Biomacromolecules 化学-高分子科学
CiteScore
10.60
自引率
4.80%
发文量
417
审稿时长
1.6 months
期刊介绍: Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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