具有高压缩弹性和止血功能的双交联甲基丙烯酸羧甲基豌豆淀粉冷冻食品

IF 5.4 2区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yuqing Liu, Wen Zhong, Yongfeng Ai and Malcolm Xing*, 
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引用次数: 0

摘要

淀粉作为一种丰富的可再生天然材料,在生物医学领域引起了前所未有的兴趣。羧化淀粉颗粒已被研究用于局部止血,但粉末可能不能提供物理保护或支持伤口。在这里,我们制备了甲基丙烯酸羧甲基淀粉(CM-ST-MA)大孔低温凝胶海绵,该海绵含有共价和钙离子双网络。第二种离子交联网络显著提高了材料的抗压强度和韧性,但降低了材料的溶胀率。在低Ca2+浓度(0.01 M)条件下,冷冻鱼和海绵表现出良好的压缩弹性,在高Ca2+浓度下,冷冻鱼变得更具可塑性,而干海绵变得刚性和脆性。低温冰箱具有优异的湿热稳定性,但仍可通过酶水解降解。CM-ST-MA海绵在体外实验中表现出良好的生物相容性、血液相容性和良好的止血效果。在小鼠断尾模型中,CM-ST-MA冷冻液不含或含Ca2+ (0.01 M)均能显著减少失血量和出血时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Double Cross-linked Methacrylated Carboxymethyl Pea Starch Cryogels with Highly Compressive Elasticity and Hemostatic Function

Double Cross-linked Methacrylated Carboxymethyl Pea Starch Cryogels with Highly Compressive Elasticity and Hemostatic Function

As an abundant renewable natural material, starch has attracted unprecedented interest in the biomedical field. Carboxylated starch particles have been investigated for topical hemostasis, but the powder may not provide physical protection or support for wounds. Here, we prepared macroporous cryogel sponges of methacrylated carboxymethyl starch (CM-ST-MA) containing a covalent and a calcium ionic double network. The second ionic cross-linking network enhanced the compressive strength and toughness dramatically but reduced the swelling ratios. Cryogels and sponges exhibited excellent compressive elasticity at low Ca2+ concentrations (0.01 M). Cryogels became more plastic and dry sponges became rigid and brittle at high Ca2+ concentrations. The cryogels have outstanding wet-thermal stability but are still degradable via enzymatic hydrolysis. All CM-ST-MA sponges showed excellent biocompatibility, hemocompatibility, and outstanding hemostasis in in vitro assays. In the in vivo mouse tail amputation model, both CM-ST-MA cryogels without or with Ca2+ (0.01 M) reduced the blood loss and bleeding time significantly.

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来源期刊
Biomacromolecules
Biomacromolecules 化学-高分子科学
CiteScore
10.60
自引率
4.80%
发文量
417
审稿时长
1.6 months
期刊介绍: Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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