99mtc标记的苯磺酰胺衍生物包裹的柠檬酸金纳米颗粒作为吉祥的肿瘤靶向。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Adli A Selim, Tamer M Sakr, Basma M Essa, Galal H Sayed, Kurls E Anwer
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引用次数: 0

摘要

磺胺衍生物是一类重要的药用化合物。金纳米颗粒(AuNPs)通过靶向递送提供精确的癌症治疗,具有高载药能力和低毒性。本研究旨在开发和评价99mtc标记的苯磺酰胺衍生物包裹的柠檬酸金纳米颗粒作为肿瘤靶向药物。合成了一种新型的含吡啶部分的苯磺酰胺衍生物。化合物3(4-(3-氰-4-(2,4-二氯苯基)-6-苯基吡啶-2-基)氨基)- n-(二氨基乙烯)苯磺酰胺)对MCF-7细胞具有显著的抗癌活性。采用化学还原法制备化合物3-柠檬酸盐- aunps。对合成的纳米平台进行了全面的检测,包括zeta电位、大小分析、放射化学产率和荷瘤小鼠体内生物分布。该纳米平台稳定性好,粒径最佳(AuNPs粒径为9 nm), [99mTc] tc -化合物3放射化学纯度高(88.31±2.14%)。体内研究显示,静脉注射的[99mTc] tc -化合物3-柠檬酸盐- aunps在肿瘤中积累,具有很高的靶非靶比。这些发现验证了新型[99mTc] tc -化合物3-柠檬酸盐- aunps平台作为肿瘤靶向药物的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

<sup>99m</sup>Tc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting.

<sup>99m</sup>Tc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting.

<sup>99m</sup>Tc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting.

99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting.

Sulfonamide derivatives are a significant class of medicinal compounds. Gold nanoparticles (AuNPs) offer precise cancer treatment through targeted delivery, boasting high drug-loading capacity and low toxicity. This study aimed to develop and evaluate 99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as a tumor-targeting agent. A novel benzenesulfonamide derivative bearing a pyridine moiety was synthesized. Compound 3 (4-((3-cyano-4-(2,4-dichlorophenyl)-6-phenylpyridin-2-yl)amino)-N-(diaminomethylene)benzenesulfonamide) exhibited remarkable anti-cancer activity against MCF-7 cells. The chemical reduction method was employed to create compound 3-citrate-AuNPs. A comprehensive examination of the synthesized nano-platform was conducted, including zeta potential, size analysis, radiochemical yield, and in-vivo biodistribution in tumor-bearing mice. The nano-platform was successfully produced with good stability, optimal particle size (9 nm diameter for AuNPs), and high radiochemical purity for [99mTc]Tc-compound 3 (88.31 ± 2.14%). In-vivo investigations revealed that intravenously administered [99mTc]Tc-compound 3-citrate-AuNPs accumulated in tumors with a high target-to-non-target ratio. The findings validate the efficacy of the novel [99mTc]Tc-compound 3-citrate-AuNPs platform as a tumor-targeting agent.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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