探讨肥胖和血糖特征与视网膜静脉闭塞的关系:单变量和多变量孟德尔随机化研究。

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Weichen Yuan, Xin Xu, Xiran Zhang, Wenqi Fan, Wenkai Zhou, Fangkun Zhao
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引用次数: 0

摘要

目的:探讨肥胖、血糖特征与视网膜静脉阻塞(RVO)之间的遗传联系。方法:从IEU Open GWAS数据库中公开的欧洲参与者的全基因组关联研究(GWAS)中提取肥胖和血糖特征的汇总统计数据。与临床诊断的RVO的遗传关联来自FinnGenresearch项目(372例病例和182,573例对照)。采用双样本孟德尔随机化(MR)和多变量随机化(MVMR)分析分别确定总效应和直接效应。结果:调整后的错误发现率(罗斯福),主inverse-variance-weighted (IVW)方法表明,每1个RVO增加的优势比偏差增加身体质量指数(BMI) (OR = 1.94, 95% CI: 1.23—-3.08,p-FDR = 0.025),腰围(OR = 2.4, 95% CI: 1.36—-4.24,p-FDR = 0.019),空腹血糖(OR = 5.01, 95% CI: 2 - 12.55, p-FDR = 0.0067)和两个小时的葡萄糖(OR = 3.17, 95% CI: 1.63—-6.18,p-FDR = 0.0067)。较高的全身无脂质量(OR = 0.45, 95% CI: 0.26-0.8,p-FDR = 0.025)是RVO的潜在保护因素。此外,MVMR结果显示,BMI、全身无脂质量、空腹血糖和2小时血糖是直接影响RVO发病的独立因素。结论:我们的综合MR分析表明BMI、全身无脂质量、空腹血糖、两小时血糖和RVO之间存在显著的遗传关联。本研究强调了体重、血糖管理和身体活动对RVO一级预防和控制的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Associations of Obesity and Glycemic Traits with Retinal Vein Occlusion: A Univariate and Multivariable Mendelian Randomization Study.

Purpose: To explore the genetic links between obesity, glycemic traits and retinal vein occlusion (RVO).

Methods: Summary-level statistics for obesity and glycemic traits were extracted from publicly available genome-wide association studies (GWAS) of European participants in the IEU Open GWAS database. Genetic associations with clinically diagnosed RVO were obtained from the FinnGenresearch project (372 cases and 182,573 controls). Two-sample Mendelian randomization (MR) and multivariate MR (MVMR) analysis were performed to determine the total effect and direct effect, respectively.

Results: After adjustment for the false discovery rate (FDR), the primary inverse-variance-weighted (IVW) methods indicated that the odds ratios of RVO increased with per 1-standard deviation increased in body mass index (BMI) (OR = 1.94, 95% CI: 1.23-3.08,p-FDR = 0.025), waist circumference (OR = 2.4, 95% CI: 1.36-4.24, p-FDR = 0.019), fasting glucose (OR = 5.01, 95% CI: 2-12.55, p-FDR = 0.0067) and two-hour glucose (OR = 3.17, 95% CI: 1.63-6.18,p-FDR = 0.0067). Higher whole-body fat-free mass (OR = 0.45, 95% CI: 0.26-0.8,p-FDR = 0.025) is a potential protective factor for RVO. In addition, the results of MVMR showed that BMI, whole-body fat-free mass, fasting glucose and two-hour glucose were independent factors that had a direct impact on the onset of RVO.

Conclusions: Our comprehensive MR analysis suggested significant genetic associations between BMI, whole-body fat-free mass, fasting glucose, two-hour glucose and RVO. This study highlighted the importance of weight, blood glucose management and physical activity for primary prevention and control of RVO.

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来源期刊
Ophthalmic epidemiology
Ophthalmic epidemiology 医学-眼科学
CiteScore
3.70
自引率
5.60%
发文量
61
审稿时长
6-12 weeks
期刊介绍: Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.
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