Efficacy and safety of microfocused ultrasound for temporary eyebrow lift and glabellar wrinkle reduction.

Microfocused ultrasound (MFU) is a noninvasive treatment method that is widely used for skin tightening. In this study, we investigated the efficacy and safety of a novel MFU device for temporary eyebrow lifting and glabellar wrinkle reduction. In this prospective, single-center, single-arm, and open-label study, 38 patients were enrolled. Each patient was treated with MFU at the forehead and lateral eye areas. The treatment efficacy was measured at weeks 4, 8, 12, and 16 by calculating the average eyebrow height (AEH), maximal eyebrow height (MEH), patient satisfaction score, and glabellar Line Scale (GLS) score. Moreover, adverse events were recorded. The AEH was elevated with a mean difference of 1.99 mm at week 4 and remained elevated at week 16 with a mean difference of 1.57 mm. (P < 0.0001, respectively). In addition, the mean MEH increased by 2.21 mm at week 4 and by 1.63 mm at week 16 (P < 0.0001, respectively). Glabellar wrinkles were temporarily alleviated in some patients, with 71.05% of patients showing an improvement of one point or more in their GLS score at week 4. No serious adverse events were reported. MFU is an effective and safe treatment for temporary eyebrow lifting and glabellar wrinkle reduction.