{"title":"以肌酐为基础的肾小球滤过率受损在泰国个体切换到多替格拉韦：说明胱抑素C检测的作用，以帮助临床决策。","authors":"Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu","doi":"10.1186/s12981-025-00712-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Data about impact of switch to dolutegravir (DTG)-based antiretroviral therapy (ART) on estimated glomerular filtration rate (eGFR) in Asians are scarce. RV254/SEARCH010 is a prospective observational cohort in Bangkok, Thailand with ART initiation during acute HIV infection (AHI) where participants switched to DTG-based ART.</p><p><strong>Methods: </strong>Participants started Efavirenz (EFV)-based ART during AHI (n = 214) and switched to DTG-based ART after a median of 97 weeks (IQR 61-145). GFR was estimated by serum creatinine (eGFR<sub>cre</sub>) every 24 weeks before and after switch. Estimated GFR by cystatin C (eGFR<sub>cystC</sub>) was ordered at clinician's discretion for decreased eGFR<sub>cre</sub> after switch. Random-effect linear regression model was used to assess changes in eGFR<sub>cre</sub> over 96 weeks from starting ART, and from switching to DTG.</p><p><strong>Results: </strong>At study entry, 20 participants (9.3%) had eGFR<sub>cre</sub> < 90 ml/min/1.73 m<sup>2</sup>. During EFV-based ART, an additional 17 (8%) developed eGFR<sub>cre</sub> < 90 ml/min/1.73 m<sup>2</sup>, nearly all transient, while mean eGFR<sub>cre</sub> remained stable and within normal range. At switch to DTG, 21 (9.8%) had eGFR<sub>cre</sub> < 90 ml/min/1.73 m<sup>2</sup> but an additional 116 (54%) developed eGFR<sub>cre</sub> < 90 ml/min/1.73 m<sup>2</sup> during follow-up with eGFR<sub>cre</sub> decrease being mostly persistent. Mean eGFR<sub>cre</sub> decreased 20.8% from 117.0 to 92.4 ml/min/1.73 m<sup>2</sup> (p < 0.001). Among 20 post-switch participants with eGFR<sub>cystC</sub> measured within 4 weeks of eGFR<sub>cre</sub> < 90 mL/min/1.73 m<sup>2</sup>, 13 (65%) had normal kidney function by eGFR<sub>cystC</sub>.</p><p><strong>Conclusions: </strong>Persistent eGFR<sub>cre</sub> decrease to < 90 ml/min/1.73 m<sup>2</sup> after switch to DTG was common in this Thai population. eGFR<sub>cystC</sub> was helpful to identify individuals with clinically significant decrease in kidney function and obviate unnecessary ART modifications. Trial registration Clinical Trials Registry Number: ClininicalTrials.gov NCT00796146.</p>","PeriodicalId":7503,"journal":{"name":"AIDS Research and Therapy","volume":"22 1","pages":"15"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804080/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making.\",\"authors\":\"Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan, Denise Hsu\",\"doi\":\"10.1186/s12981-025-00712-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Data about impact of switch to dolutegravir (DTG)-based antiretroviral therapy (ART) on estimated glomerular filtration rate (eGFR) in Asians are scarce. RV254/SEARCH010 is a prospective observational cohort in Bangkok, Thailand with ART initiation during acute HIV infection (AHI) where participants switched to DTG-based ART.</p><p><strong>Methods: </strong>Participants started Efavirenz (EFV)-based ART during AHI (n = 214) and switched to DTG-based ART after a median of 97 weeks (IQR 61-145). GFR was estimated by serum creatinine (eGFR<sub>cre</sub>) every 24 weeks before and after switch. Estimated GFR by cystatin C (eGFR<sub>cystC</sub>) was ordered at clinician's discretion for decreased eGFR<sub>cre</sub> after switch. Random-effect linear regression model was used to assess changes in eGFR<sub>cre</sub> over 96 weeks from starting ART, and from switching to DTG.</p><p><strong>Results: </strong>At study entry, 20 participants (9.3%) had eGFR<sub>cre</sub> < 90 ml/min/1.73 m<sup>2</sup>. During EFV-based ART, an additional 17 (8%) developed eGFR<sub>cre</sub> < 90 ml/min/1.73 m<sup>2</sup>, nearly all transient, while mean eGFR<sub>cre</sub> remained stable and within normal range. At switch to DTG, 21 (9.8%) had eGFR<sub>cre</sub> < 90 ml/min/1.73 m<sup>2</sup> but an additional 116 (54%) developed eGFR<sub>cre</sub> < 90 ml/min/1.73 m<sup>2</sup> during follow-up with eGFR<sub>cre</sub> decrease being mostly persistent. Mean eGFR<sub>cre</sub> decreased 20.8% from 117.0 to 92.4 ml/min/1.73 m<sup>2</sup> (p < 0.001). Among 20 post-switch participants with eGFR<sub>cystC</sub> measured within 4 weeks of eGFR<sub>cre</sub> < 90 mL/min/1.73 m<sup>2</sup>, 13 (65%) had normal kidney function by eGFR<sub>cystC</sub>.</p><p><strong>Conclusions: </strong>Persistent eGFR<sub>cre</sub> decrease to < 90 ml/min/1.73 m<sup>2</sup> after switch to DTG was common in this Thai population. eGFR<sub>cystC</sub> was helpful to identify individuals with clinically significant decrease in kidney function and obviate unnecessary ART modifications. Trial registration Clinical Trials Registry Number: ClininicalTrials.gov NCT00796146.</p>\",\"PeriodicalId\":7503,\"journal\":{\"name\":\"AIDS Research and Therapy\",\"volume\":\"22 1\",\"pages\":\"15\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-02-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11804080/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AIDS Research and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12981-025-00712-0\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS Research and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12981-025-00712-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Impaired creatinine-based estimated glomerular filtration rate in Thai individuals switching to dolutegravir: illustrating the role of cystatin C testing to aid clinical decision making.
Introduction: Data about impact of switch to dolutegravir (DTG)-based antiretroviral therapy (ART) on estimated glomerular filtration rate (eGFR) in Asians are scarce. RV254/SEARCH010 is a prospective observational cohort in Bangkok, Thailand with ART initiation during acute HIV infection (AHI) where participants switched to DTG-based ART.
Methods: Participants started Efavirenz (EFV)-based ART during AHI (n = 214) and switched to DTG-based ART after a median of 97 weeks (IQR 61-145). GFR was estimated by serum creatinine (eGFRcre) every 24 weeks before and after switch. Estimated GFR by cystatin C (eGFRcystC) was ordered at clinician's discretion for decreased eGFRcre after switch. Random-effect linear regression model was used to assess changes in eGFRcre over 96 weeks from starting ART, and from switching to DTG.
Results: At study entry, 20 participants (9.3%) had eGFRcre < 90 ml/min/1.73 m2. During EFV-based ART, an additional 17 (8%) developed eGFRcre < 90 ml/min/1.73 m2, nearly all transient, while mean eGFRcre remained stable and within normal range. At switch to DTG, 21 (9.8%) had eGFRcre < 90 ml/min/1.73 m2 but an additional 116 (54%) developed eGFRcre < 90 ml/min/1.73 m2 during follow-up with eGFRcre decrease being mostly persistent. Mean eGFRcre decreased 20.8% from 117.0 to 92.4 ml/min/1.73 m2 (p < 0.001). Among 20 post-switch participants with eGFRcystC measured within 4 weeks of eGFRcre < 90 mL/min/1.73 m2, 13 (65%) had normal kidney function by eGFRcystC.
Conclusions: Persistent eGFRcre decrease to < 90 ml/min/1.73 m2 after switch to DTG was common in this Thai population. eGFRcystC was helpful to identify individuals with clinically significant decrease in kidney function and obviate unnecessary ART modifications. Trial registration Clinical Trials Registry Number: ClininicalTrials.gov NCT00796146.
期刊介绍：
AIDS Research and Therapy publishes articles on basic science, translational, clinical, social, epidemiological, behavioral and educational sciences articles focused on the treatment and prevention of HIV/AIDS, and the search for the cure. The Journal publishes articles on novel and developing treatment strategies for AIDS as well as on the outcomes of established treatment strategies. Original research articles on animal models that form an essential part of the AIDS treatment research are also considered
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
