Cameron B Seger, Kirk A Muñoz, Laura R Adams, Ahmed Kamr, Phillip Lerche, Carolina H Ricco Pereira, Audrey Wanstrath, Ramiro E Toribio
{"title":"精氨酸抗利尿激素、胃饥饿素、5-羟基吲哚乙酸和P物质似乎不是狗恶心的可靠生物标志物。","authors":"Cameron B Seger, Kirk A Muñoz, Laura R Adams, Ahmed Kamr, Phillip Lerche, Carolina H Ricco Pereira, Audrey Wanstrath, Ramiro E Toribio","doi":"10.2460/ajvr.24.11.0342","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine if ACTH, cortisol, arginine vasopressin (AVP), ghrelin, 5-hydroxyindoleacetic acid (5-HIAA), and substance P (SP) blood biomarkers associated with nausea in humans have similar associations in dogs.</p><p><strong>Methods: </strong>7 healthy, mixed hound dogs were nausea scored using videotaped observations, and concentrations of ACTH, cortisol, AVP, ghrelin, 5-HIAA, and SP were measured in blood at baseline, after 0.5 mg/kg, IM, morphine administration, and following administration of the treatment drug. Data collection occurred from October 20 through November 24, 2023. Treatments were saline 0.1 mL/kg (S) and propofol 0.5 mg/kg (P1), 1.0 mg/kg (P2), and 1.5 mg/kg (P3) administered IV 20 minutes after morphine administration using a randomized, crossover design with a 7-day washout between treatments.</p><p><strong>Results: </strong>Nausea scores increased at 5 minutes and over time in all treatments. Adrenocorticotropic hormone concentrations were lower in P2 versus P1, P2 versus S, and P3 versus S at the 50-minute time point. At 50 minutes, cortisol concentrations were lower in P3 versus S, P2 versus S, and P3 versus P1. There were no statistically significant differences in AVP, ghrelin, 5-HIAA, or SP concentrations between treatments or over time.</p><p><strong>Conclusions: </strong>AVP, ghrelin, 5-HIAA, and SP did not correlate with nausea signs in dogs. Additionally, propofol, at the subhypnotic doses administered, did not significantly decrease signs of nausea.</p><p><strong>Clinical relevance: </strong>ACTH and cortisol, but not AVP, ghrelin, 5-HIAA, and SP, concentrations appeared to be associated with signs of nausea in dogs. Propofol was not effective at decreasing signs of nausea at the administered dosages.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Arginine vasopressin, ghrelin, 5-hydroxyindoleacetic acid, and substance P do not appear to be reliable biomarkers of nausea in dogs.\",\"authors\":\"Cameron B Seger, Kirk A Muñoz, Laura R Adams, Ahmed Kamr, Phillip Lerche, Carolina H Ricco Pereira, Audrey Wanstrath, Ramiro E Toribio\",\"doi\":\"10.2460/ajvr.24.11.0342\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine if ACTH, cortisol, arginine vasopressin (AVP), ghrelin, 5-hydroxyindoleacetic acid (5-HIAA), and substance P (SP) blood biomarkers associated with nausea in humans have similar associations in dogs.</p><p><strong>Methods: </strong>7 healthy, mixed hound dogs were nausea scored using videotaped observations, and concentrations of ACTH, cortisol, AVP, ghrelin, 5-HIAA, and SP were measured in blood at baseline, after 0.5 mg/kg, IM, morphine administration, and following administration of the treatment drug. Data collection occurred from October 20 through November 24, 2023. Treatments were saline 0.1 mL/kg (S) and propofol 0.5 mg/kg (P1), 1.0 mg/kg (P2), and 1.5 mg/kg (P3) administered IV 20 minutes after morphine administration using a randomized, crossover design with a 7-day washout between treatments.</p><p><strong>Results: </strong>Nausea scores increased at 5 minutes and over time in all treatments. Adrenocorticotropic hormone concentrations were lower in P2 versus P1, P2 versus S, and P3 versus S at the 50-minute time point. At 50 minutes, cortisol concentrations were lower in P3 versus S, P2 versus S, and P3 versus P1. There were no statistically significant differences in AVP, ghrelin, 5-HIAA, or SP concentrations between treatments or over time.</p><p><strong>Conclusions: </strong>AVP, ghrelin, 5-HIAA, and SP did not correlate with nausea signs in dogs. Additionally, propofol, at the subhypnotic doses administered, did not significantly decrease signs of nausea.</p><p><strong>Clinical relevance: </strong>ACTH and cortisol, but not AVP, ghrelin, 5-HIAA, and SP, concentrations appeared to be associated with signs of nausea in dogs. Propofol was not effective at decreasing signs of nausea at the administered dosages.</p>\",\"PeriodicalId\":7754,\"journal\":{\"name\":\"American journal of veterinary research\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-02-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of veterinary research\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.2460/ajvr.24.11.0342\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/ajvr.24.11.0342","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"Print","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Arginine vasopressin, ghrelin, 5-hydroxyindoleacetic acid, and substance P do not appear to be reliable biomarkers of nausea in dogs.
Objective: To determine if ACTH, cortisol, arginine vasopressin (AVP), ghrelin, 5-hydroxyindoleacetic acid (5-HIAA), and substance P (SP) blood biomarkers associated with nausea in humans have similar associations in dogs.
Methods: 7 healthy, mixed hound dogs were nausea scored using videotaped observations, and concentrations of ACTH, cortisol, AVP, ghrelin, 5-HIAA, and SP were measured in blood at baseline, after 0.5 mg/kg, IM, morphine administration, and following administration of the treatment drug. Data collection occurred from October 20 through November 24, 2023. Treatments were saline 0.1 mL/kg (S) and propofol 0.5 mg/kg (P1), 1.0 mg/kg (P2), and 1.5 mg/kg (P3) administered IV 20 minutes after morphine administration using a randomized, crossover design with a 7-day washout between treatments.
Results: Nausea scores increased at 5 minutes and over time in all treatments. Adrenocorticotropic hormone concentrations were lower in P2 versus P1, P2 versus S, and P3 versus S at the 50-minute time point. At 50 minutes, cortisol concentrations were lower in P3 versus S, P2 versus S, and P3 versus P1. There were no statistically significant differences in AVP, ghrelin, 5-HIAA, or SP concentrations between treatments or over time.
Conclusions: AVP, ghrelin, 5-HIAA, and SP did not correlate with nausea signs in dogs. Additionally, propofol, at the subhypnotic doses administered, did not significantly decrease signs of nausea.
Clinical relevance: ACTH and cortisol, but not AVP, ghrelin, 5-HIAA, and SP, concentrations appeared to be associated with signs of nausea in dogs. Propofol was not effective at decreasing signs of nausea at the administered dosages.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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