新生儿接种卡介苗后是否需要全身传播以预防结核分枝杆菌？

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI:10.1093/infdis/jiaf051

Tobias R Kollmann, Nelly Amenyogbe, Frederik Schaltz-Buchholzer, Ole Bæk, James Campbell, David J Lynn, Anita J Campbell, Peter Aaby, Christine Stabell Benn, Mihai G Netea, Maziar Divangahi

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引用次数: 0

摘要

结核病是由结核分枝杆菌（Mtb）引起的，是导致死亡的主要原因。卡介苗（BCG）是唯一获得许可的结核病疫苗。临床前研究表明，成人静脉注射卡介苗可提高对结核病的保护作用。我们假设，人类新生儿皮内注射卡介苗可导致低级别卡介苗菌血症，而这种全身传播可提高对结核分枝杆菌感染的保护。这一假设是基于包括动物和人类研究在内的支持性观察。这是一个可检验的假设，并提供可立即采取行动的见解，以推进全球防治结核病的努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Is Systemic Dissemination of BCG Following Neonatal Vaccination Required for Protection Against Mycobacterium tuberculosis?

查看原文本刊更多论文

Is Systemic Dissemination of BCG Following Neonatal Vaccination Required for Protection Against Mycobacterium tuberculosis?

Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and is a leading cause of death. BCG is the only licensed TB vaccine. Preclinical studies have shown that in adults, intravenous administration of BCG improves protection against TB. We hypothesize that intradermal administration of BCG to the human newborn leads to low-grade BCG bacteremia and that this systemic dissemination improves protection against Mtb infection. This hypothesis is based on supporting observations including animal and human studies. It is a testable hypothesis and offers to deliver immediately actionable insight to advance the global efforts against TB.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.