二甲嗪输注对剖腹探查术马术后出院存活率影响的回顾性评价。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia Pub Date : 2025-03-01 DOI:10.1016/j.vaa.2025.01.006

Rachel A. Reed , Anna T. Carroll , Stephanie C. Dantino , Jane E. Quandt , Michele Barletta , Daniel M. Sakai

{"title":"二甲嗪输注对剖腹探查术马术后出院存活率影响的回顾性评价。","authors":"Rachel A. Reed , Anna T. Carroll , Stephanie C. Dantino , Jane E. Quandt , Michele Barletta , Daniel M. Sakai","doi":"10.1016/j.vaa.2025.01.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To determine the influence of xylazine infusion on survival to discharge and describe the associated intraoperative requirement for isoflurane, use of positive inotropes and vasopressors, and recovery time in horses undergoing exploratory laparotomy.</div></div><div><h3>Study design</h3><div>Retrospective cohort study.</div></div><div><h3>Animals</h3><div>A total of 352 horses.</div></div><div><h3>Methods</h3><div>Medical records of horses undergoing anesthesia for exploratory laparotomy from January 2018 to December 2023 were reviewed. Data collected included survival to discharge, results of diagnostic tests, end tidal isoflurane concentration (FE'Iso), use of vasopressors/inotropes, and duration of recovery in horses with (WX) or without (WOX) intraoperative xylazine infusion. For survival to discharge, univariable and multivariable logistic regression was performed adjusting for the effects of other infusions. For all other variables, descriptive statistics were performed.</div></div><div><h3>Results</h3><div>Survival to discharge was 80.6% and 78.5% for WX and WOX, respectively (<em>p</em> = 0.431). Mean ± standard deviation FE'Iso was 0.82 ± 0.21% and 0.94 ± 0.21% for WX and WOX, respectively. Dobutamine was given to 159/166 (95.8%) and 176/186 (94.6%) horses at a rate of 1 (0.1–3.0) μg kg<sup>-1</sup> minute<sup>-1</sup> and 1 (0.25–3.0) μg kg<sup>-1</sup> minute<sup>-1</sup> in WX and WOX, respectively. Norepinephrine infusion was given to 15/166 (9%) and 27/186 (15%) horses at a rate of 0.2 (0.025–0.4) μg kg<sup>-1</sup> minute<sup>-1</sup> and 0.2 (0.05–0.7) μg kg<sup>-1</sup> minute<sup>-1</sup> in WX and WOX, respectively. Median (range) recovery times were 70 (15–310) minutes and 75 (20–313) minutes for WX and WOX, respectively.</div></div><div><h3>Conclusions</h3><div>The use of xylazine as a part of a balanced anesthesia protocol in horses undergoing exploratory laparotomy did not negatively affect survival to discharge.</div></div><div><h3>Clinical relevance</h3><div>Xylazine infusion as part of a balanced anesthesia protocol appears promising based on this single-center study. Further research is required to fully explore the risks and benefits of xylazine infusions in this context.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 2","pages":"Pages 221-227"},"PeriodicalIF":1.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Retrospective evaluation of the effect of xylazine infusion on survival to discharge in horses undergoing exploratory laparotomy for colic\",\"authors\":\"Rachel A. Reed , Anna T. Carroll , Stephanie C. Dantino , Jane E. Quandt , Michele Barletta , Daniel M. Sakai\",\"doi\":\"10.1016/j.vaa.2025.01.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To determine the influence of xylazine infusion on survival to discharge and describe the associated intraoperative requirement for isoflurane, use of positive inotropes and vasopressors, and recovery time in horses undergoing exploratory laparotomy.</div></div><div><h3>Study design</h3><div>Retrospective cohort study.</div></div><div><h3>Animals</h3><div>A total of 352 horses.</div></div><div><h3>Methods</h3><div>Medical records of horses undergoing anesthesia for exploratory laparotomy from January 2018 to December 2023 were reviewed. Data collected included survival to discharge, results of diagnostic tests, end tidal isoflurane concentration (FE'Iso), use of vasopressors/inotropes, and duration of recovery in horses with (WX) or without (WOX) intraoperative xylazine infusion. For survival to discharge, univariable and multivariable logistic regression was performed adjusting for the effects of other infusions. For all other variables, descriptive statistics were performed.</div></div><div><h3>Results</h3><div>Survival to discharge was 80.6% and 78.5% for WX and WOX, respectively (<em>p</em> = 0.431). Mean ± standard deviation FE'Iso was 0.82 ± 0.21% and 0.94 ± 0.21% for WX and WOX, respectively. Dobutamine was given to 159/166 (95.8%) and 176/186 (94.6%) horses at a rate of 1 (0.1–3.0) μg kg<sup>-1</sup> minute<sup>-1</sup> and 1 (0.25–3.0) μg kg<sup>-1</sup> minute<sup>-1</sup> in WX and WOX, respectively. Norepinephrine infusion was given to 15/166 (9%) and 27/186 (15%) horses at a rate of 0.2 (0.025–0.4) μg kg<sup>-1</sup> minute<sup>-1</sup> and 0.2 (0.05–0.7) μg kg<sup>-1</sup> minute<sup>-1</sup> in WX and WOX, respectively. Median (range) recovery times were 70 (15–310) minutes and 75 (20–313) minutes for WX and WOX, respectively.</div></div><div><h3>Conclusions</h3><div>The use of xylazine as a part of a balanced anesthesia protocol in horses undergoing exploratory laparotomy did not negatively affect survival to discharge.</div></div><div><h3>Clinical relevance</h3><div>Xylazine infusion as part of a balanced anesthesia protocol appears promising based on this single-center study. Further research is required to fully explore the risks and benefits of xylazine infusions in this context.</div></div>\",\"PeriodicalId\":23626,\"journal\":{\"name\":\"Veterinary anaesthesia and analgesia\",\"volume\":\"52 2\",\"pages\":\"Pages 221-227\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary anaesthesia and analgesia\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1467298725000066\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary anaesthesia and analgesia","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1467298725000066","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

目的：探讨噻嗪输注对剖腹探查马存活至出院的影响，并描述术中异氟醚的需求、正性肌力和血管加压药物的使用以及恢复时间。研究设计：回顾性队列研究。动物：共有352匹马。方法：回顾2018年1月至2023年12月麻醉马剖腹探查术的病历。收集的数据包括术中输注（WX）或未输注（WOX）的马的生存至出院、诊断试验结果、末潮汐异氟烷浓度（FE'Iso）、血管加压药/肌力药物的使用以及恢复时间。对于存活至出院，进行单变量和多变量logistic回归，调整其他输注的影响。对所有其他变量进行描述性统计。结果：WX组和WOX组的出院生存率分别为80.6%和78.5% （p = 0.431）。WX和WOX的平均±标准差FE'Iso分别为0.82±0.21%和0.94±0.21%。分别以1 (0.1 ~ 3.0)μ kg-1 min -1和1 (0.25 ~ 3.0)μ kg-1 min -1剂量给药159/166匹马（95.8%）和176/186匹马（94.6%）。分别以0.2 (0.025-0.4)μg kg-1 min -1和0.2 (0.05-0.7)μg kg-1 min -1给药15/166（9%）和27/186（15%）匹马。WX和WOX的中位（范围）恢复时间分别为70（15-310）分钟和75（20-313）分钟。结论：在进行剖腹探查术的马中，使用噻嗪作为平衡麻醉方案的一部分，对其存活至出院没有负面影响。临床相关性：根据这项单中心研究，羟嗪输注作为平衡麻醉方案的一部分似乎很有希望。在这种情况下，需要进一步的研究来充分探索氯嗪输注的风险和益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Retrospective evaluation of the effect of xylazine infusion on survival to discharge in horses undergoing exploratory laparotomy for colic

Objective

To determine the influence of xylazine infusion on survival to discharge and describe the associated intraoperative requirement for isoflurane, use of positive inotropes and vasopressors, and recovery time in horses undergoing exploratory laparotomy.

Study design

Retrospective cohort study.

Animals

A total of 352 horses.

Methods

Medical records of horses undergoing anesthesia for exploratory laparotomy from January 2018 to December 2023 were reviewed. Data collected included survival to discharge, results of diagnostic tests, end tidal isoflurane concentration (FE'Iso), use of vasopressors/inotropes, and duration of recovery in horses with (WX) or without (WOX) intraoperative xylazine infusion. For survival to discharge, univariable and multivariable logistic regression was performed adjusting for the effects of other infusions. For all other variables, descriptive statistics were performed.

Results

Survival to discharge was 80.6% and 78.5% for WX and WOX, respectively (p = 0.431). Mean ± standard deviation FE'Iso was 0.82 ± 0.21% and 0.94 ± 0.21% for WX and WOX, respectively. Dobutamine was given to 159/166 (95.8%) and 176/186 (94.6%) horses at a rate of 1 (0.1–3.0) μg kg^-1 minute^-1 and 1 (0.25–3.0) μg kg^-1 minute^-1 in WX and WOX, respectively. Norepinephrine infusion was given to 15/166 (9%) and 27/186 (15%) horses at a rate of 0.2 (0.025–0.4) μg kg^-1 minute^-1 and 0.2 (0.05–0.7) μg kg^-1 minute^-1 in WX and WOX, respectively. Median (range) recovery times were 70 (15–310) minutes and 75 (20–313) minutes for WX and WOX, respectively.

Conclusions

The use of xylazine as a part of a balanced anesthesia protocol in horses undergoing exploratory laparotomy did not negatively affect survival to discharge.

Clinical relevance

Xylazine infusion as part of a balanced anesthesia protocol appears promising based on this single-center study. Further research is required to fully explore the risks and benefits of xylazine infusions in this context.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Veterinary anaesthesia and analgesia 农林科学-兽医学

CiteScore

3.10

自引率

17.60%

发文量

审稿时长

97 days

期刊介绍： Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome: the basic sciences; pathophysiology of disease as it relates to anaesthetic management equipment intensive care chemical restraint of animals including laboratory animals, wildlife and exotic animals welfare issues associated with pain and distress education in veterinary anaesthesia and analgesia. Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.